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Pgm3 Gene Detail
Summary
  • Symbol
    Pgm3
  • Name
    phosphoglucomutase 3
  • Synonyms
    2810473H05Rik, GlcNAc-P mutase, Pgm-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97566
    NCBI Gene: 109785
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:86436430-86453895 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.58 cM, cytoband E3.2
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97566
 protein coding gene Chr9:86423997-86453927 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035096
 protein coding gene Chr9:87384134-87401486 (-)
A/J MGP_AJ_G0035077
 protein coding gene Chr9:84339259-84356711 (-)
AKR/J MGP_AKRJ_G0035005
 protein coding gene Chr9:86330207-86349157 (-)
BALB/cJ MGP_BALBcJ_G0035065
 protein coding gene Chr9:83975373-83996162 (-)
C3H/HeJ MGP_C3HHeJ_G0034777
 protein coding gene Chr9:86792487-86812015 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035589
 protein coding gene Chr9:89738211-89758607 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032496
 protein coding gene Chr9:83099334-83117323 (-)
CAST/EiJ MGP_CASTEiJ_G0034095
 protein coding gene Chr9:87268964-87286077 (-)
CBA/J MGP_CBAJ_G0034750
 protein coding gene Chr9:92929729-92947918 (-)
DBA/2J MGP_DBA2J_G0034908
 protein coding gene Chr9:83879987-83914451 (-)
FVB/NJ MGP_FVBNJ_G0034851
 protein coding gene Chr9:82987055-83004490 (-)
LP/J MGP_LPJ_G0034989
 protein coding gene Chr9:87596458-87614909 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034893
 protein coding gene Chr9:94517132-94537105 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035609
 protein coding gene Chr9:86441044-86460184 (-)
PWK/PhJ MGP_PWKPhJ_G0033799
 protein coding gene Chr9:84063872-84081849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033635
 protein coding gene Chr9:86652723-86673584 (-)
WSB/EiJ MGP_WSBEiJ_G0034212
 protein coding gene Chr9:86476176-86496153 (-)



Homology
more
  • Human Ortholog
    PGM3, phosphoglucomutase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGM3, phosphoglucomutase 3
  • Synonyms
    AGM1, IMD23, PAGM, PGM 3
  • Links
    NCBI Gene ID: 5238
    neXtProt AC: NX_O95394
    UniProt: O95394

  • Chr Location
    6q14.1; chr6:83147324-83193936 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PGM3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit male infertility, anemia, leukopenia, thrombocytopenia, abnormal pancreatic and salivary gland morphology, and splenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    109
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056131 Ensembl Gene Model | MGI Sequence Detail 17466 C57BL/6J ±  kb
    transcript ENSMUST00000070064 Ensembl | MGI Sequence Detail 2666 Not Applicable  
    polypeptide ENSMUSP00000070871 Ensembl | MGI Sequence Detail 542 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012617 phosphoacetylglucosamine mutase
      (term hierarchy)
    • PDB
      1WJW
    • EC
      5.4.2.3
    • InterPro Domains
      IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
      IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III
      IPR016066 Alpha-D-phosphohexomutase, conserved site
      IPR005843 Alpha-D-phosphohexomutase, C-terminal
      IPR036900 Alpha-D-phosphohexomutase, C-terminal domain superfamily
      IPR016657 Phosphoacetylglucosamine mutase
      IPR049023 Phosphoacetylglucosamine mutase AMG1, domain II
      IPR049022 Phosphoacetylglucosamine mutase AMG1, domain III
    • GlyGen
      Q9CYR6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13277, MGD-MRK-13280, MGI:1920033, MGI:2143369, MGI:2143392
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:6621 Nadeau JH, et al., Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man. Biochem Genet. 1981 Jun;19(5-6):465-74
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory