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Serpine1 Gene Detail
Summary
  • Symbol
    Serpine1
  • Name
    serine (or cysteine) peptidase inhibitor, clade E, member 1
  • Synonyms
    PAI-1, PAI1, Planh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97608
    NCBI Gene: 18787
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137090358-137101122 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97608
 protein coding gene Chr5:137090358-137101126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030216
 protein coding gene Chr5:141781073-141799610 (-)
A/J MGP_AJ_G0030184
 protein coding gene Chr5:135634272-135644838 (-)
AKR/J MGP_AKRJ_G0030117
 protein coding gene Chr5:140037555-140048255 (-)
BALB/cJ MGP_BALBcJ_G0030194
 protein coding gene Chr5:136993845-137005759 (-)
C3H/HeJ MGP_C3HHeJ_G0029910
 protein coding gene Chr5:140656415-140673835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030646
 protein coding gene Chr5:147049765-147060312 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029320
 protein coding gene Chr5:140067630-140082153 (-)
CBA/J MGP_CBAJ_G0029880
 protein coding gene Chr5:152800882-152819904 (-)
DBA/2J MGP_DBA2J_G0030031
 protein coding gene Chr5:135530207-135541690 (-)
FVB/NJ MGP_FVBNJ_G0029986
 protein coding gene Chr5:134711120-134721739 (-)
LP/J MGP_LPJ_G0030120
 protein coding gene Chr5:142212874-142228494 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030018
 protein coding gene Chr5:155697321-155713163 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030687
 protein coding gene Chr5:139864394-139875628 (-)
PWK/PhJ MGP_PWKPhJ_G0029033
 protein coding gene Chr5:134620664-134632032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028869
 protein coding gene Chr5:137452645-137463064 (-)
WSB/EiJ MGP_WSBEiJ_G0029393
 protein coding gene Chr5:140602719-140613344 (-)



Homology
more
  • Human Ortholog
    SERPINE1, serpin family E member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINE1, serpin family E member 1
  • Synonyms
    PAI, PAI-1, PAI1, PLANH1
  • Links
    NCBI Gene ID: 5054
    neXtProt AC: NX_P05121
    UniProt: P05121

  • Chr Location
    7q22.1; chr7:101127104-101139247 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Serpine1 mouse models; 26 with human SERPINE1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 4 alleles in 8 genetic backgrounds
    15 phenotypes from multigenic genotypes
    295 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although mice homozygous for disruptions in this gene display an essentially normal phenotype, a mild blood clotting defect does exist. Mice homozygous for an allele with amino acid substitutions exhibit decreased sensitivity to LPS-induced lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    37
  • cDNA Data
    24
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037411 Ensembl Gene Model | MGI Sequence Detail 10765 C57BL/6J ±  kb
    transcript ENSMUST00000041388 Ensembl | MGI Sequence Detail 3011 Not Applicable  
    polypeptide ENSMUSP00000039586 Ensembl | MGI Sequence Detail 402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 24
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13344
    References
    more
    • Summaries
      All 443
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 18
      Phenotypes 295
    • Earliest
      J:32471 Prendergast GC, et al., The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol. 1990 Mar;10(3):1265-9
    • Latest
      J:354880 LaMarche NM, et al., An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024 Jan;625(7993):166-174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory