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Plk1 Gene Detail
Summary
  • Symbol
    Plk1
  • Name
    polo like kinase 1
  • Synonyms
    Plk, STPK13
  • Feature Type
    protein coding gene
  • IDs
    MGI:97621
    NCBI Gene: 18817
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:121758662-121769096 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 65.52 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    400 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97621
 protein coding gene Chr7:121758658-121769107 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032953
 protein coding gene Chr7:126234993-126246281 (+)
A/J MGP_AJ_G0032936
 protein coding gene Chr7:122959820-122971599 (+)
AKR/J MGP_AKRJ_G0032868
 protein coding gene Chr7:126086555-126098968 (+)
BALB/cJ MGP_BALBcJ_G0032941
 protein coding gene Chr7:122653122-122663512 (+)
C3H/HeJ MGP_C3HHeJ_G0032651
 protein coding gene Chr7:126009232-126020692 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033447
 protein coding gene Chr7:131210462-131221290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030419
 protein coding gene Chr7:124285923-124296276 (+)
CAST/EiJ MGP_CASTEiJ_G0031979
 protein coding gene Chr7:117801001-117813642 (+)
CBA/J MGP_CBAJ_G0032624
 protein coding gene Chr7:135619031-135636283 (+)
DBA/2J MGP_DBA2J_G0032776
 protein coding gene Chr7:120962428-120972846 (+)
FVB/NJ MGP_FVBNJ_G0032729
 protein coding gene Chr7:120814109-120824723 (+)
LP/J MGP_LPJ_G0032870
 protein coding gene Chr7:127674575-127685866 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032761
 protein coding gene Chr7:136987376-137001427 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033467
 protein coding gene Chr7:125094019-125105756 (+)
PWK/PhJ MGP_PWKPhJ_G0031687
 protein coding gene Chr7:113891941-113903146 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031533
 protein coding gene Chr7:111870011-111880539 (+)
WSB/EiJ MGP_WSBEiJ_G0032092
 protein coding gene Chr7:125998339-126010955 (+)



Homology
more
  • Human Ortholog
    PLK1, polo like kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLK1, polo like kinase 1
  • Synonyms
    PLK, STPK13
  • Links
    NCBI Gene ID: 5347
    neXtProt AC: NX_P53350
    UniProt: P53350

  • Chr Location
    16p12.2; chr16:23677656-23690367 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display lethality before implantation, embryonic growth arrest, and impaired mitosis. Mice heterozygous for a null mutation display increased tumor incidence and increased incidence of aneuploidy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    143
  • cDNA Data
    20
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030867 Ensembl Gene Model | MGI Sequence Detail 10435 C57BL/6J ±  kb
    transcript ENSMUST00000033154 Ensembl | MGI Sequence Detail 2199 Not Applicable  
    polypeptide ENSMUSP00000033154 Ensembl | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 7
      cDNA 22
      Primer pair 8
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13361
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 46
      Gene Ontology 17
      Phenotypes 28
    • Earliest
      J:12876 Clay FJ, et al., Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4882-6
    • Latest
      J:346372 Kolesova H, et al., Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure. Front Endocrinol (Lausanne). 2024;15:1344074
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory