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Prl Gene Detail
Summary
  • Symbol
    Prl
  • Name
    prolactin
  • Synonyms
    Prl1a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97762
    NCBI Gene: 19109
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:27241553-27249187 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 12.25 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97762
 protein coding gene Chr13:27241553-27249188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020390
 protein coding gene Chr13:24655189-24663564 (+)
A/J MGP_AJ_G0020339
 protein coding gene Chr13:24133519-24140935 (+)
AKR/J MGP_AKRJ_G0020319
 protein coding gene Chr13:24425116-24432796 (+)
BALB/cJ MGP_BALBcJ_G0020337
 protein coding gene Chr13:24113290-24120651 (+)
C3H/HeJ MGP_C3HHeJ_G0020141
 protein coding gene Chr13:24496554-24504306 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020774
 protein coding gene Chr13:25506605-25514193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018362
 protein coding gene Chr13:22755437-22763086 (+)
CAST/EiJ MGP_CASTEiJ_G0019658
 protein coding gene Chr13:24225120-24232587 (+)
CBA/J MGP_CBAJ_G0020095
 protein coding gene Chr13:26512854-26524339 (+)
DBA/2J MGP_DBA2J_G0020221
 protein coding gene Chr13:23663513-23670899 (+)
FVB/NJ MGP_FVBNJ_G0020205
 protein coding gene Chr13:23261955-23269541 (+)
LP/J MGP_LPJ_G0020294
 protein coding gene Chr13:24905750-24913144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020232
 protein coding gene Chr13:26835878-26846539 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020816
 protein coding gene Chr13:24299471-24307322 (+)
PWK/PhJ MGP_PWKPhJ_G0019412
 protein coding gene Chr13:23624387-23632223 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019228
 protein coding gene Chr13:23179933-23187722 (+)
WSB/EiJ MGP_WSBEiJ_G0019718
 protein coding gene Chr13:24471506-24480573 (+)



Homology
more
  • Human Ortholog
    PRL, prolactin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRL, prolactin
  • Synonyms
    GHA1
  • Links
    NCBI Gene ID: 5617
    neXtProt AC: NX_P01236
    UniProt: P01236

  • Chr Location
    6p22.3; chr6:22287244-22302835 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRL associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    29
  • cDNA Data
    1364
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19109 NCBI Gene Model | MGI Sequence Detail 7635 C57BL/6J ±  kb
    transcript NM_011164 RefSeq | MGI Sequence Detail 895 ZRU/MplStud  
    polypeptide P06879 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1371
      Genomic 1
      cDNA 1364
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13613, MGI:2145398
    References
    more
    • Summaries
      All 229
      Developmental Gene Expression 81
      Gene Ontology 14
      Phenotypes 43
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory