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Ptger1 Gene Detail
Summary
  • Symbol
    Ptger1
  • Name
    prostaglandin E receptor 1 (subtype EP1)
  • Synonyms
    42kDa, EP1, Ptgerep1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97793
    NCBI Gene: 19216
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84393307-84399382 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97793
 protein coding gene Chr8:84393171-84399385 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033837
 protein coding gene Chr8:84506337-84512254 (+)
A/J MGP_AJ_G0033820
 protein coding gene Chr8:81206806-81212723 (+)
AKR/J MGP_AKRJ_G0033746
 protein coding gene Chr8:83596235-83602152 (+)
BALB/cJ MGP_BALBcJ_G0033813
 protein coding gene Chr8:81303654-81309571 (+)
C3H/HeJ MGP_C3HHeJ_G0033523
 protein coding gene Chr8:84220492-84226409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034333
 protein coding gene Chr8:87729135-87735055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031275
 protein coding gene Chr8:74989080-74994983 (+)
CAST/EiJ MGP_CASTEiJ_G0032853
 protein coding gene Chr8:83619446-83625356 (+)
CBA/J MGP_CBAJ_G0033501
 protein coding gene Chr8:90876967-90882884 (+)
DBA/2J MGP_DBA2J_G0033654
 protein coding gene Chr8:80844551-80850468 (+)
FVB/NJ MGP_FVBNJ_G0033600
 protein coding gene Chr8:79756973-79762893 (+)
LP/J MGP_LPJ_G0033744
 protein coding gene Chr8:84613588-84619505 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033642
 protein coding gene Chr8:93375283-93381200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034350
 protein coding gene Chr8:83573002-83578922 (+)
PWK/PhJ MGP_PWKPhJ_G0032557
 protein coding gene Chr8:80058197-80064112 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032394
 protein coding gene Chr8:82374000-82379901 (+)
WSB/EiJ MGP_WSBEiJ_G0032966
 protein coding gene Chr8:83977464-83983381 (+)



Homology
more
  • Human Ortholog
    PTGER1, prostaglandin E receptor 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGER1, prostaglandin E receptor 1
  • Synonyms
    EP1
  • Links
    NCBI Gene ID: 5731
    neXtProt AC: NX_P34995
    UniProt: P34995

  • Chr Location
    19p13.12; chr19:14472466-14475354 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 5 alleles in 8 genetic backgrounds
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice may exhibit partial prenatal lethality, pain threshold abnormalities, behavioral disinhibition in response to stress, low blood pressure, defects in type IV hypersensitivity reactions, resistance to chemically induced tumors and impaired response to water deprivation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    97
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019464 Ensembl Gene Model | MGI Sequence Detail 6076 C57BL/6J ±  kb
    transcript ENSMUST00000019608 Ensembl | MGI Sequence Detail 4694 Not Applicable  
    polypeptide ENSMUSP00000019608 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 4
      cDNA 14
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13660
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 108
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory