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Pth Gene Detail
Summary
  • Symbol
    Pth
  • Name
    parathyroid hormone
  • Feature Type
    protein coding gene
  • IDs
    MGI:97799
    NCBI Gene: 19226
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:112984787-112987777 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 59.19 cM, cytoband F
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97799
 protein coding gene Chr7:112984783-112987879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032875
 protein coding gene Chr7:117026742-117029740 (-)
A/J MGP_AJ_G0032858
 protein coding gene Chr7:114075998-114078996 (-)
AKR/J MGP_AKRJ_G0032790
 protein coding gene Chr7:116959508-116962506 (-)
BALB/cJ MGP_BALBcJ_G0032863
 protein coding gene Chr7:113783196-113786194 (-)
C3H/HeJ MGP_C3HHeJ_G0032573
 protein coding gene Chr7:116950167-116953162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033369
 protein coding gene Chr7:121756220-121759217 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030341
 protein coding gene Chr7:115655320-115658296 (-)
CAST/EiJ MGP_CASTEiJ_G0031901
 protein coding gene Chr7:108577076-108580068 (-)
CBA/J MGP_CBAJ_G0032546
 protein coding gene Chr7:125803384-125806379 (-)
DBA/2J MGP_DBA2J_G0032698
 protein coding gene Chr7:112158203-112161198 (-)
FVB/NJ MGP_FVBNJ_G0032651
 protein coding gene Chr7:112011582-112014579 (-)
LP/J MGP_LPJ_G0032792
 protein coding gene Chr7:118527681-118530679 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032683
 protein coding gene Chr7:127384843-127387841 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033389
 protein coding gene Chr7:115952767-115955762 (-)
PWK/PhJ MGP_PWKPhJ_G0031608
 protein coding gene Chr7:105005192-105008187 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031456
 protein coding gene Chr7:102723263-102726255 (-)
WSB/EiJ MGP_WSBEiJ_G0032014
 protein coding gene Chr7:116827127-116830123 (-)



Homology
more
  • Human Ortholog
    PTH, parathyroid hormone
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTH, parathyroid hormone
  • Synonyms
    FIH1, PTH1
  • Links
    NCBI Gene ID: 5741
    neXtProt AC: NX_P01270
    UniProt: P01270

  • Chr Location
    11p15.3; chr11:13492054-13496181 (-)  GRCh38
  • MGI Vertebrate Homology
    Pth stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: PTH
  • Protein SuperFamily
    PTH
  • Gene Tree
    Pth
Human Diseases
more
  • Diseases
    7 with human PTH associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    2 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit diminished cartilage mineralization, and reductions in angiopoietin-1, neovascularization, metaphyseal osteoblasts, and trabecular bone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    51
  • cDNA Data
    21
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059077 Ensembl Gene Model | MGI Sequence Detail 2991 C57BL/6J ±  kb
    transcript ENSMUST00000079793 Ensembl | MGI Sequence Detail 710 Not Applicable  
    polypeptide ENSMUSP00000078723 Ensembl | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR003625 Parathyroid hormone
      IPR001415 Parathyroid hormone/parathyroid hormone-related protein
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 3
      cDNA 21
      Primer pair 4
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13667
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 17
      Gene Ontology 13
      Phenotypes 43
    • Earliest
      J:7342 Heinrich G, et al., Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem. 1984 Mar 10;259(5):3320-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory