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Rbp2 Gene Detail
Summary
  • Symbol
    Rbp2
  • Name
    retinol binding protein 2, cellular
  • Synonyms
    Crbp-2, CrbpII, Rbp-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97877
    NCBI Gene: 19660
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98372590-98391824 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.37 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97877
 protein coding gene Chr9:98368168-98391834 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035155
 protein coding gene Chr9:99786531-99812030 (+)
A/J MGP_AJ_G0035137
 protein coding gene Chr9:96279588-96304662 (+)
AKR/J MGP_AKRJ_G0035068
 protein coding gene Chr9:98629880-98653532 (+)
BALB/cJ MGP_BALBcJ_G0035129
 protein coding gene Chr9:95962256-95985903 (+)
C3H/HeJ MGP_C3HHeJ_G0034839
 protein coding gene Chr9:99028277-99051858 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035649
 protein coding gene Chr9:102638038-102661574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032548
 protein coding gene Chr9:94051357-94075221 (+)
CAST/EiJ MGP_CASTEiJ_G0034150
 protein coding gene Chr9:98829367-98855161 (+)
CBA/J MGP_CBAJ_G0034807
 protein coding gene Chr9:106171752-106197474 (+)
DBA/2J MGP_DBA2J_G0034969
 protein coding gene Chr9:95792283-95815882 (+)
FVB/NJ MGP_FVBNJ_G0034917
 protein coding gene Chr9:94622772-94646445 (+)
LP/J MGP_LPJ_G0035048
 protein coding gene Chr9:100039932-100065202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034956
 protein coding gene Chr9:108114302-108137868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035671
 protein coding gene Chr9:98852352-98880288 (+)
PWK/PhJ MGP_PWKPhJ_G0033857
 protein coding gene Chr9:96000184-96023593 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033693
 protein coding gene Chr9:98912762-98936505 (+)
WSB/EiJ MGP_WSBEiJ_G0034270
 protein coding gene Chr9:98736079-98760585 (+)



Homology
more
  • Human Ortholog
    RBP2, retinol binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBP2, retinol binding protein 2
  • Synonyms
    CRABP-II, CRBP2, CRBPII, RBPC2
  • Links
    NCBI Gene ID: 5948
    neXtProt AC: NX_P50120
    UniProt: P50120

  • Chr Location
    3q23; chr3:139452884-139480747 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Rbp2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    11 strains or lines available
Saturable vitamin A (retinol) uptake is impaired in homozygous mutant mice. Serum retinol levels are unaffected when with normal dietary intake, however, pups of homozygous dams fed a marginal retinol diet show increased neonatal lethality due to inadequate retinal transport to the fetus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    10
  • cDNA Data
    70
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19660 NCBI Gene Model | MGI Sequence Detail 19235 C57BL/6J ±  kb
transcript NM_009034 RefSeq | MGI Sequence Detail 672 ZRU/MplStud  
polypeptide Q08652 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    Genomic 2
    cDNA 71
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13788, MGD-MRK-13793, MGD-MRK-2132
References
more
  • Summaries
    All 64
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:8604 Demmer LA, et al., The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. J Biol Chem. 1987 Feb 25;262(6):2458-67
  • Latest
    J:357965 Calderon RM, et al., Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein 2 and Retinoid Actions. Endocrinology. 2022 Jul 1;163(7)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory