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Rbp3 Gene Detail
Summary
  • Symbol
    Rbp3
  • Name
    retinol binding protein 3, interstitial
  • Synonyms
    Irbp, Rbp-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97878
    NCBI Gene: 19661
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33675960-33686173 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97878
 protein coding gene Chr14:33675960-33686176 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021161
 protein coding gene Chr14:27286446-27296509 (+)
A/J MGP_AJ_G0021109
 protein coding gene Chr14:26231400-26241463 (+)
AKR/J MGP_AKRJ_G0021086
 protein coding gene Chr14:27399693-27409810 (+)
BALB/cJ MGP_BALBcJ_G0021113
 protein coding gene Chr14:26415504-26425646 (+)
C3H/HeJ MGP_C3HHeJ_G0020896
 protein coding gene Chr14:27316011-27326153 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021545
 protein coding gene Chr14:28334988-28345077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019107
 protein coding gene Chr14:26269292-26279277 (+)
CAST/EiJ MGP_CASTEiJ_G0020421
 protein coding gene Chr14:27131580-27141903 (+)
CBA/J MGP_CBAJ_G0020863
 protein coding gene Chr14:29368484-29378626 (+)
DBA/2J MGP_DBA2J_G0020985
 protein coding gene Chr14:26269154-26279296 (+)
FVB/NJ MGP_FVBNJ_G0020969
 protein coding gene Chr14:26223120-26233236 (+)
LP/J MGP_LPJ_G0021054
 protein coding gene Chr14:27623522-27633663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020995
 protein coding gene Chr14:28525061-28535175 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021578
 protein coding gene Chr14:27225531-27235673 (+)
PWK/PhJ MGP_PWKPhJ_G0020169
 protein coding gene Chr14:25759950-25770091 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019993
 protein coding gene Chr14:26844356-26854436 (+)
WSB/EiJ MGP_WSBEiJ_G0020476
 protein coding gene Chr14:27289485-27299625 (+)



Homology
more
  • Human Ortholog
    RBP3, retinol binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBP3, retinol binding protein 3
  • Synonyms
    D10S64, D10S65, D10S66, IRBP, RBPI, RP66
  • Links
    NCBI Gene ID: 5949
    neXtProt AC: NX_P10745
    UniProt: P10745

  • Chr Location
    10q11.22; chr10:47348363-47357881 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RBP3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience photoreceptor degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    25
  • cDNA Data
    123
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041534 Ensembl Gene Model | MGI Sequence Detail 10214 C57BL/6J ±  kb
    transcript ENSMUST00000035695 Ensembl | MGI Sequence Detail 5295 Not Applicable  
    polypeptide ENSMUSP00000040249 Ensembl | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013820 retinol-binding protein 3
      (term hierarchy)
    • InterPro Domains
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR005151 Tail specific protease
    • GlyGen
      P49194 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 135
      Genomic 5
      cDNA 128
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11462, MGD-MRK-13789, MGD-MRK-13794
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026 (Abstr.)
    • Latest
      J:353299 Getz TE, et al., Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory