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Trim30a Gene Detail
Summary
  • Symbol
    Trim30a
  • Name
    tripartite motif-containing 30A
  • Synonyms
    Rpt-1, Rpt1, Trim30
  • Feature Type
    protein coding gene
  • IDs
    MGI:98178
    NCBI Gene: 20128
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:104058232-104114400 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.69 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1186 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98178
 protein coding gene Chr7:104058232-104114400 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032716
 protein coding gene Chr7:107572979-107596698 (-)
A/J MGP_AJ_G0032691
 protein coding gene Chr7:104748944-104778108 (-)
AKR/J MGP_AKRJ_G0032624
 protein coding gene Chr7:107370442-107426259 (-)
BALB/cJ MGP_BALBcJ_G0032701
 protein coding gene Chr7:104478524-104522323 (-)
C3H/HeJ MGP_C3HHeJ_G0032412
 protein coding gene Chr7:107627886-107676610 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033197
 protein coding gene Chr7:111763535-111811857 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0031739
 protein coding gene Chr7:99357941-99408219 (-)
CBA/J MGP_CBAJ_G0032380
 protein coding gene Chr7:115540100-115640174 (-)
DBA/2J MGP_DBA2J_G0032534
 protein coding gene Chr7:103083927-103105195 (-)
FVB/NJ MGP_FVBNJ_G0032488
 protein coding gene Chr7:102893522-102894798 (-)
LP/J MGP_LPJ_G0032627
 protein coding gene Chr7:108892134-108940822 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032519
 protein coding gene Chr7:117034095-117059665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033224
 protein coding gene Chr7:106560057-106583881 (-)
PWK/PhJ MGP_PWKPhJ_G0031455
 protein coding gene Chr7:96084590-96113054 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031301
 protein coding gene Chr7:93707533-93753923 (-)
WSB/EiJ MGP_WSBEiJ_G0031856
 protein coding gene Chr7:107227775-107255616 (-)



Homology
more
  • Human Ortholog
    TRIM5, tripartite motif containing 5
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM5, tripartite motif containing 5
  • Synonyms
    RNF88, TRIM5alpha
  • Links
    NCBI Gene ID: 85363
    neXtProt AC: NX_Q9C035
    UniProt: Q9C035

  • Chr Location
    11p15.4; chr11:5588635-5938619 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased CD4/CD8 ratio with age, an abnormal CD4+ T cell response upon TCR activation, and reduced effector function of CD4+ T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    36
  • cDNA Data
    94
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20128 NCBI Gene Model | MGI Sequence Detail 56169 C57BL/6J ±  kb
transcript NM_001357467 RefSeq | MGI Sequence Detail 3809 ZRU/MplStud  
polypeptide P15533 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    cDNA 94
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14205, MGD-MRK-14206
References
more
  • Summaries
    All 57
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:9134 Patarca R, et al., rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1 [published erratum appears in Proc Natl Acad Sci U S A 1988 Jul;85(14):5224. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2733-7
  • Latest
    J:349812 Schafer A, et al., Mapping of susceptibility loci for Ebola virus pathogenesis in mice. Cell Rep. 2024 May 28;43(5):114127
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory