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Rxra Gene Detail
Summary
  • Symbol
    Rxra
  • Name
    retinoid X receptor alpha
  • Synonyms
    9530071D11Rik, RXR alpha 1, RXRalpha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98214
    NCBI Gene: 20181
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27566452-27652969 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2019 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98214
 protein coding gene Chr2:27566452-27653331 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025516
 protein coding gene Chr2:25674176-25761956 (+)
A/J MGP_AJ_G0025493
 protein coding gene Chr2:24722168-24809907 (+)
AKR/J MGP_AKRJ_G0025463
 protein coding gene Chr2:25538542-25631795 (+)
BALB/cJ MGP_BALBcJ_G0025489
 protein coding gene Chr2:24836534-24925774 (+)
C3H/HeJ MGP_C3HHeJ_G0025250
 protein coding gene Chr2:25452588-25543905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025933
 protein coding gene Chr2:26564430-26652907 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023344
 protein coding gene Chr2:23527294-23614974 (+)
CAST/EiJ MGP_CASTEiJ_G0024713
 protein coding gene Chr2:25343878-25437348 (+)
CBA/J MGP_CBAJ_G0025228
 protein coding gene Chr2:27477036-27568074 (+)
DBA/2J MGP_DBA2J_G0025361
 protein coding gene Chr2:24535599-24622685 (+)
FVB/NJ MGP_FVBNJ_G0025323
 protein coding gene Chr2:24296652-24384370 (+)
LP/J MGP_LPJ_G0025447
 protein coding gene Chr2:25631536-25718370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025354
 protein coding gene Chr2:27481136-27572237 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025992
 protein coding gene Chr2:25448868-25539071 (+)
PWK/PhJ MGP_PWKPhJ_G0024461
 protein coding gene Chr2:24322950-24410770 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024261
 protein coding gene Chr2:25610304-25702216 (+)
WSB/EiJ MGP_WSBEiJ_G0024782
 protein coding gene Chr2:25581730-25673007 (+)



Homology
more
  • Human Ortholog
    RXRA, retinoid X receptor alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RXRA, retinoid X receptor alpha
  • Synonyms
    NR2B1, RXR-alpha, RXRalpha
  • Links
    NCBI Gene ID: 6256
    neXtProt AC: NX_P19793
    UniProt: P19793

  • Chr Location
    9q34.2; chr9:134317098-134440585 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Rxra mouse models; 1 with human RXRA associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    165 phenotypes from 11 alleles in 11 genetic backgrounds
    39 phenotypes from multigenic genotypes
    4 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null embryos have multiple organ defects and die of cardiac failure by E14.5. Gene ablation in liver, prostate, fat or epidermis tissue-specifically affects development, function and/or neoplasia. Hypomorphic mutants develop alopecia, progressively severe dermal cysts and late corneal opacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    155
  • GO References
    54
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1093
  • Tissues
    186
  • cDNA Data
    28
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015846 Ensembl Gene Model | MGI Sequence Detail 86518 C57BL/6J ±  kb
    transcript ENSMUST00000238913 Ensembl | MGI Sequence Detail 1631 Not Applicable  
    polypeptide ENSMUSP00000159198 Ensembl | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 6
      cDNA 31
      Primer pair 17
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14264, MGI:1925990
    References
    more
    • Summaries
      All 311
      Developmental Gene Expression 72
      Diseases 3
      Gene Ontology 54
      Phenotypes 100
    • Earliest
      J:2326 Mangelsdorf DJ, et al., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992 Mar;6(3):329-44
    • Latest
      J:342474 Manoharan I, et al., The Transcription Factor RXRalpha in CD11c+ APCs Regulates Intestinal Immune Homeostasis and Inflammation. J Immunol. 2023 Sep 1;211(5):853-861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory