Scd2 MGI Mouse Gene Detail - MGI:98240 - stearoyl-Coenzyme A desaturase 2

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Scd2 Gene Detail

Symbol

Scd2
Name

stearoyl-Coenzyme A desaturase 2
Synonyms

Scd-2

Feature Type

protein coding gene
IDs

MGI:98240
NCBI Gene: 20250
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr19:44282115-44295303 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 37.98 cM
Mapping Data

5 experiments

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SNPs within 2kb

372 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_98240	protein coding gene	Chr19:44282113-44295303 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025168	protein coding gene	Chr19:43753476-43766660 (+)
A/J	MGP_AJ_G0025145	protein coding gene	Chr19:41670340-41683519 (+)
AKR/J	MGP_AKRJ_G0025113	protein coding gene	Chr19:42986681-43001232 (+)
BALB/cJ	MGP_BALBcJ_G0025139	protein coding gene	Chr19:41711388-41726340 (+)
C3H/HeJ	MGP_C3HHeJ_G0024899	protein coding gene	Chr19:43161173-43175022 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025582	protein coding gene	Chr19:44834733-44849270 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022996	protein coding gene	Chr19:40957808-40971085 (+)
CAST/EiJ	MGP_CASTEiJ_G0024364	protein coding gene	Chr19:42865381-42879863 (+)
CBA/J	MGP_CBAJ_G0024879	protein coding gene	Chr19:47052963-47066574 (+)
DBA/2J	MGP_DBA2J_G0025011	protein coding gene	Chr19:41490261-41503440 (+)
FVB/NJ	MGP_FVBNJ_G0024972	protein coding gene	Chr19:41245880-41260921 (+)
LP/J	MGP_LPJ_G0025097	protein coding gene	Chr19:43706430-43721004 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025003	protein coding gene	Chr19:46553826-46567031 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025640	protein coding gene	Chr19:43071086-43087441 (+)
PWK/PhJ	MGP_PWKPhJ_G0024113	protein coding gene	Chr19:41387541-41400716 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023917	protein coding gene	Chr19:41781241-41797537 (+)
WSB/EiJ	MGP_WSBEiJ_G0024434	protein coding gene	Chr19:43204660-43217816 (+)

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Human Ortholog

SCD, stearoyl-CoA desaturase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCD, stearoyl-CoA desaturase
Synonyms

FADS5, hSCD1, MSTP008, SCD1, SCDOS
Links

HGNC:10571

NCBI Gene ID: 6319

neXtProt AC: NX_O00767

UniProt: O00767
Chr Location

10q24.31; chr10:100347233-100364826 (+) GRCh38

MGI Vertebrate Homology

Scd2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SCD
Gene Tree

Scd2

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
1 images
12 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display neonatal lethality with variable penetrance depending on strain background, impaired skin barrier function, abnormal epidermal morphology, and abnormal lipid homeostasis in the skin and liver.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

141
cDNA Data

16
Literature Summary

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS29848.1

Ensembl

ENSMUSG00000025203 (Evidence)
NCBI Gene

20250

Representative Sequences				Length	Strain/Species	Flank
	genomic	20250	NCBI Gene Model \| MGI Sequence Detail	13189	C57BL/6J	± kb
	transcript	NM_009128	RefSeq \| MGI Sequence Detail	5453	ZRU/MplStud
	polypeptide	P13011	UniProt \| EBI \| MGI Sequence Detail	358	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015922 stearoyl-CoA desaturase 2

(term hierarchy)
EC

1.14.19.1
InterPro Domains

IPR015876 Acyl-CoA desaturase

IPR005804 Fatty acid desaturase domain

IPR001522 Fatty acid desaturase type 1, conserved site

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All nucleic 25

Genomic 1

cDNA 16

Primer pair 5

Other 3

Microarray probesets 2

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MGD-MRK-14306, MGD-MRK-14308, MGI:3584399

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Summaries

All 65

Developmental Gene Expression 16

Gene Ontology 7

Phenotypes 12
Earliest

J:9973 Kaestner KH, et al., Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1989 Sep 5;264(25):14755-61
Latest

J:349928 York AG, et al., IL-10 constrains sphingolipid metabolism to limit inflammation. Nature. 2024 Mar;627(8004):628-635

TSS for Scd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5523	Chr19:44282442-44282480 (+)	346 bp
Tssr156564	Chr19:44282512-44282538 (+)	410 bp
Tssr156565	Chr19:44282581-44282588 (+)	470 bp
Tssr156566	Chr19:44282597-44282607 (+)	487 bp
Tssr156567	Chr19:44282632-44282645 (+)	524 bp
Tssr156568	Chr19:44282671-44282685 (+)	563 bp
Tssr156569	Chr19:44282695-44282698 (+)	582 bp
Tssr156570	Chr19:44282704-44282712 (+)	593 bp
Tssr156571	Chr19:44282735-44282743 (+)	624 bp
Tssr156572	Chr19:44283341-44283358 (+)	1,235 bp
Tssr156573	Chr19:44283359-44283377 (+)	1,253 bp
Tssr156574	Chr19:44283405-44283419 (+)	1,297 bp
Tssr156575	Chr19:44283436-44283457 (+)	1,332 bp
Tssr156576	Chr19:44283465-44283483 (+)	1,359 bp
Tssr156577	Chr19:44283526-44283566 (+)	1,431 bp
Tssr156578	Chr19:44285071-44285092 (+)	2,967 bp
Tssr156579	Chr19:44285278-44285299 (+)	3,174 bp
Tssr156580	Chr19:44286499-44286566 (+)	4,418 bp
Tssr156585	Chr19:44291678-44291694 (+)	9,571 bp
Tssr156586	Chr19:44291740-44291749 (+)	9,630 bp
Tssr156587	Chr19:44291775-44291785 (+)	9,665 bp
Tssr156588	Chr19:44291786-44291851 (+)	9,704 bp
Tssr156589	Chr19:44291883-44291894 (+)	9,774 bp
Tssr156590	Chr19:44291907-44291916 (+)	9,797 bp
Tssr156591	Chr19:44291977-44291999 (+)	9,873 bp
Tssr156592	Chr19:44292252-44292272 (+)	10,147 bp
Tssr156593	Chr19:44293036-44293056 (+)	10,931 bp
Tssr156594	Chr19:44294358-44294385 (+)	12,257 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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