About   Help   FAQ
Ccl5 Gene Detail
Summary
  • Symbol
    Ccl5
  • Name
    C-C motif chemokine ligand 5
  • Synonyms
    MuRantes, RANTES, Scya5, SISd, TCP228
  • Feature Type
    protein coding gene
  • IDs
    MGI:98262
    NCBI Gene: 20304
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83416604-83421344 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.66 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98262
 protein coding gene Chr11:83416604-83421344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018852
 protein coding gene Chr11:84859467-84864213 (-)
A/J MGP_AJ_G0018819
 protein coding gene Chr11:81635597-81640343 (-)
AKR/J MGP_AKRJ_G0018789
 protein coding gene Chr11:84076504-84081258 (-)
BALB/cJ MGP_BALBcJ_G0018792
 protein coding gene Chr11:82048224-82052964 (-)
C3H/HeJ MGP_C3HHeJ_G0018606
 protein coding gene Chr11:84123470-84128216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019244
 protein coding gene Chr11:87455568-87460312 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016878
 protein coding gene Chr11:78765545-78769900 (-)
CAST/EiJ MGP_CASTEiJ_G0018161
 protein coding gene Chr11:84707303-84711972 (-)
CBA/J MGP_CBAJ_G0018577
 protein coding gene Chr11:91231089-91235835 (-)
DBA/2J MGP_DBA2J_G0018685
 protein coding gene Chr11:81236144-81240898 (-)
FVB/NJ MGP_FVBNJ_G0018674
 protein coding gene Chr11:80722341-80727085 (-)
LP/J MGP_LPJ_G0018755
 protein coding gene Chr11:85419435-85424181 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018701
 protein coding gene Chr11:91400751-91405499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019284
 protein coding gene Chr11:84339823-84344576 (-)
PWK/PhJ MGP_PWKPhJ_G0017930
 protein coding gene Chr11:81996423-82001292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017722
 protein coding gene Chr11:83879070-83883757 (-)
WSB/EiJ MGP_WSBEiJ_G0018212
 protein coding gene Chr11:84201241-84206003 (-)



Homology
more
  • Human Ortholog
    CCL5, C-C motif chemokine ligand 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL5, C-C motif chemokine ligand 5
  • Synonyms
    D17S136E, eoCP, RANTES, SCYA5, SISd, SIS-delta, TCP228
  • Links
    NCBI Gene ID: 6352
    neXtProt AC: NX_P13501
    UniProt: P13501

  • Chr Location
    17q12; chr17:35871491-35880793 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human CCL5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    6
  • Targeted
    6
  • Transgenic
    3
  • Genomic Mutations
    2 involving Ccl5
  • Find Mice (IMSR)
    11 strains or lines available
Homozygous mutation of this gene results in decreased ear and footpad swelling following injection with DHT. T cell proliferative response is also impaired in mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    61
  • cDNA Data
    21
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20304 NCBI Gene Model | MGI Sequence Detail 4741 C57BL/6J ±  kb
transcript NM_013653 RefSeq | MGI Sequence Detail 579 ZRU/MplStud  
polypeptide P30882 UniProt | EBI | MGI Sequence Detail 91 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 3
    cDNA 21
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14336
References
more
  • Summaries
    All 183
    Developmental Gene Expression 15
    Gene Ontology 16
    Phenotypes 59
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:346467 Liao X, et al., Adipose stem cells control obesity-induced T cell infiltration into adipose tissue. Cell Rep. 2024 Mar 15;43(3):113963
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory