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Cripto Gene Detail
Summary
  • Symbol
    Cripto
  • Name
    cripto, EGF-CFC family member
  • Synonyms
    CR1, Tdgf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98658
    NCBI Gene: 21667
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110768676-110775226 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 60.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98658
 protein coding gene Chr9:110768671-110775226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035365
 protein coding gene Chr9:113136413-113143360 (-)
A/J MGP_AJ_G0035346
 protein coding gene Chr9:109005153-109011883 (-)
AKR/J MGP_AKRJ_G0035277
 protein coding gene Chr9:111715724-111722223 (-)
BALB/cJ MGP_BALBcJ_G0035341
 protein coding gene Chr9:108764069-108771581 (-)
C3H/HeJ MGP_C3HHeJ_G0035049
 protein coding gene Chr9:112223073-112230638 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035863
 protein coding gene Chr9:116256210-116262674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032749
 protein coding gene Chr9:106223096-106229269 (-)
CAST/EiJ MGP_CASTEiJ_G0034355
 protein coding gene Chr9:112025895-112032339 (-)
CBA/J MGP_CBAJ_G0035016
 protein coding gene Chr9:120539168-120545594 (-)
DBA/2J MGP_DBA2J_G0035175
 protein coding gene Chr9:108465833-108472368 (-)
FVB/NJ MGP_FVBNJ_G0035122
 protein coding gene Chr9:107306603-107313744 (-)
LP/J MGP_LPJ_G0035254
 protein coding gene Chr9:113425205-113432574 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035162
 protein coding gene Chr9:121848997-121858141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035883
 protein coding gene Chr9:112067502-112074659 (-)
PWK/PhJ MGP_PWKPhJ_G0034062
 protein coding gene Chr9:108712532-108719280 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033897
 protein coding gene Chr9:112149350-112155974 (-)
WSB/EiJ MGP_WSBEiJ_G0034476
 protein coding gene Chr9:111937558-111945191 (-)



Homology
more
  • Human Ortholog
    CRIPTO, cripto, EGF-CFC family member
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRIPTO, cripto, EGF-CFC family member
  • Synonyms
    CR, CR-1, CRGF, TDGF1
  • Links
    NCBI Gene ID: 6997
    neXtProt AC: NX_P13385
    UniProt: P13385

  • Chr Location
    3p21.31; chr3:46574534-46582457 (+)  GRCh38
  • Human Ortholog
    CRIPTO3, cripto, EGF-CFC family member 3
  • Synonyms
    CR-3, CRIPTO, CRIPTO-3, TDGF1P3, TDGF2, TDGF3
  • Links
    NCBI Gene ID: 6998
    UniProt: P51864

  • Chr Location
    Xq23; chrX:110520896-110523021 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CRIPTO associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 5 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    3 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in rostral-caudal axis formation, embryonic development and heart development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    972
  • Tissues
    89
  • cDNA Data
    26
  • Literature Summary
    101
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21667 NCBI Gene Model | MGI Sequence Detail 6551 C57BL/6J ±  kb
    transcript NM_011562 RefSeq | MGI Sequence Detail 1948 ZRU/MplStud  
    polypeptide P51865 UniProt | EBI | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 1
      cDNA 28
      Primer pair 10
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14984, MGI:7488116
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 101
      Gene Ontology 23
      Phenotypes 36
    • Earliest
      J:16797 Ciccodicola A, et al., Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989 Jul;8(7):1987-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory