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Tgfb1 Gene Detail
Summary
  • Symbol
    Tgfb1
  • Name
    transforming growth factor, beta 1
  • Synonyms
    Tgfb, Tgfb-1, TGF-beta 1, TGF-beta1, TGFbeta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98725
    NCBI Gene: 21803
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25386427-25404502 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.98 cM
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98725
 protein coding gene Chr7:25386406-25404503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031876
 protein coding gene Chr7:24194813-24212884 (+)
A/J MGP_AJ_G0031855
 protein coding gene Chr7:23562063-23580216 (+)
AKR/J MGP_AKRJ_G0031784
 protein coding gene Chr7:24165790-24184667 (+)
BALB/cJ MGP_BALBcJ_G0031860
 protein coding gene Chr7:23801276-23819962 (+)
C3H/HeJ MGP_C3HHeJ_G0031581
 protein coding gene Chr7:24578187-24596221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032324
 protein coding gene Chr7:25010061-25029369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029379
 protein coding gene Chr7:24901355-24920198 (+)
CAST/EiJ MGP_CASTEiJ_G0030921
 protein coding gene Chr7:17990663-18010453 (+)
CBA/J MGP_CBAJ_G0031546
 protein coding gene Chr7:25886444-25912710 (+)
DBA/2J MGP_DBA2J_G0031700
 protein coding gene Chr7:23456158-23474233 (+)
FVB/NJ MGP_FVBNJ_G0031653
 protein coding gene Chr7:23487595-23505593 (+)
LP/J MGP_LPJ_G0031779
 protein coding gene Chr7:24472423-24490488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031690
 protein coding gene Chr7:25617009-25637983 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032356
 protein coding gene Chr7:23806317-23824389 (+)
PWK/PhJ MGP_PWKPhJ_G0030645
 protein coding gene Chr7:18406813-18425676 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030475
 protein coding gene Chr7:15131807-15152707 (+)
WSB/EiJ MGP_WSBEiJ_G0031024
 protein coding gene Chr7:24025662-24050405 (+)



Homology
more
  • Human Ortholog
    TGFB1, transforming growth factor beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFB1, transforming growth factor beta 1
  • Synonyms
    CED, DPD1, IBDIMDE, LAP, TGFB, TGFbeta, TGF-beta1
  • Links
    NCBI Gene ID: 7040
    neXtProt AC: NX_P01137
    UniProt: P01137

  • Chr Location
    19q13.2; chr19:41301587-41353922 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgfb1 mouse models; 25 with human TGFB1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
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 View 1 model
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    145 phenotypes from 8 alleles in 17 genetic backgrounds
    86 phenotypes from multigenic genotypes
    8 images
    210 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Many homozygous null mutants die in utero by day 10.5 from yolk sac vasculature and hemopoietic defects. Survivors die by 5 weeks with wasting syndrome, excess inflammatory response and tissue necrosis. On BALB/c, mice develop necroinflammatory hepatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    372
  • GO References
    80
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1758
  • Tissues
    590
  • cDNA Data
    19
  • Literature Summary
    270
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002603 Ensembl Gene Model | MGI Sequence Detail 18076 C57BL/6J ±  kb
    transcript ENSMUST00000002678 Ensembl | MGI Sequence Detail 2175 Not Applicable  
    polypeptide ENSMUSP00000002678 Ensembl | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 3
      cDNA 30
      Primer pair 36
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15063, MGD-MRK-15064, MGD-MRK-15067
    References
    more
    • Summaries
      All 1492
      Developmental Gene Expression 270
      Diseases 2
      Gene Ontology 80
      Phenotypes 210
    • Earliest
      J:23987 de Larco JE, et al., Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5
    • Latest
      J:359151 Riehl DR, et al., Reply to Chong et al.: Investigating TGFbeta1 biological activities using genetically engineered mouse strains. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2408647121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory