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Timp1 Gene Detail
Summary
  • Symbol
    Timp1
  • Name
    tissue inhibitor of metalloproteinase 1
  • Synonyms
    Clgi, MGC:7143, TIMP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98752
    NCBI Gene: 21857
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20736524-20740972 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.38 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98752
 protein coding gene ChrX:20736405-20740974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035599
 protein coding gene ChrX:15765602-15770171 (+)
A/J MGP_AJ_G0035576
 protein coding gene ChrX:15851870-15856439 (+)
AKR/J MGP_AKRJ_G0035509
 protein coding gene ChrX:16404668-16409237 (+)
BALB/cJ MGP_BALBcJ_G0035569
 protein coding gene ChrX:15619857-15624426 (+)
C3H/HeJ MGP_C3HHeJ_G0035287
 protein coding gene ChrX:15988929-15993534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036105
 protein coding gene ChrX:16184043-16188612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032969
 protein coding gene ChrX:14109238-14113807 (+)
CAST/EiJ MGP_CASTEiJ_G0034578
 protein coding gene ChrX:15281637-15286203 (+)
CBA/J MGP_CBAJ_G0035256
 protein coding gene ChrX:16924752-16929321 (+)
DBA/2J MGP_DBA2J_G0035408
 protein coding gene ChrX:15650947-15655516 (+)
FVB/NJ MGP_FVBNJ_G0035354
 protein coding gene ChrX:15561262-15565891 (+)
LP/J MGP_LPJ_G0035490
 protein coding gene ChrX:16021321-16025890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035398
 protein coding gene ChrX:17182679-17187248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036112
 protein coding gene ChrX:15688001-15692570 (+)
PWK/PhJ MGP_PWKPhJ_G0034279
 protein coding gene ChrX:14851683-14856249 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034119
 protein coding gene ChrX:15684476-15689392 (+)
WSB/EiJ MGP_WSBEiJ_G0034713
 protein coding gene ChrX:15554597-15559166 (+)



Homology
more
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMP1, TIMP metallopeptidase inhibitor 1
  • Synonyms
    CLGI, EPA, EPO, HCI, TIMP, TIMP-1
  • Links
    NCBI Gene ID: 7076
    neXtProt AC: NX_P01033
    UniProt: P01033

  • Chr Location
    Xp11.3; chrX:47582408-47586789 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show altered endometrial gland number and estrous cycles, increased uterus and testis weight, reduced female fertility, aortic aneurysms, reduced bone marrow cellularity and susceptibility to bacterial infection, and altered response to myocardium infarction and induced lung injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1127
  • Tissues
    196
  • cDNA Data
    55
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21857 NCBI Gene Model | MGI Sequence Detail 4449 C57BL/6J ±  kb
    transcript NM_001044384 RefSeq | MGI Sequence Detail 767 C57BL/6  
    polypeptide P12032 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016352 metalloproteinase inhibitor 1
      (term hierarchy)
    • InterPro Domains
      IPR001134 Netrin domain
      IPR001820 Protease inhibitor I35 (TIMP)
      IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal
      IPR030490 Tissue inhibitor of metalloproteinase, conserved site
      IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
    • GlyGen
      P12032 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 9
      cDNA 56
      Primer pair 13
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15110, MGD-MRK-2015
    References
    more
    • Summaries
      All 245
      Developmental Gene Expression 62
      Gene Ontology 10
      Phenotypes 82
    • Earliest
      J:6817 Skup D, et al., Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. Nucleic Acids Res. 1982 May 25;10(10):3069-84
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory