About   Help   FAQ
Tmod1 Gene Detail
Summary
  • Symbol
    Tmod1
  • Name
    tropomodulin 1
  • Synonyms
    erythrocyte tropomodulin, E-Tmod
  • Feature Type
    protein coding gene
  • IDs
    MGI:98775
    NCBI Gene: 21916
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46038940-46116032 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2330 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98775
 protein coding gene Chr4:46038935-46116032 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028251
 protein coding gene Chr4:44312433-44397925 (+)
A/J MGP_AJ_G0028210
 protein coding gene Chr4:42712122-42788739 (+)
AKR/J MGP_AKRJ_G0028160
 protein coding gene Chr4:43742039-43822359 (+)
BALB/cJ MGP_BALBcJ_G0028230
 protein coding gene Chr4:42807194-42885938 (+)
C3H/HeJ MGP_C3HHeJ_G0027951
 protein coding gene Chr4:44348838-44426584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028671
 protein coding gene Chr4:45956469-46043427 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025980
 protein coding gene Chr4:40101978-40178346 (+)
CAST/EiJ MGP_CASTEiJ_G0027390
 protein coding gene Chr4:43902198-43988402 (+)
CBA/J MGP_CBAJ_G0027917
 protein coding gene Chr4:47405594-47491982 (+)
DBA/2J MGP_DBA2J_G0028067
 protein coding gene Chr4:42606189-42683193 (+)
FVB/NJ MGP_FVBNJ_G0028034
 protein coding gene Chr4:41847450-41925995 (+)
LP/J MGP_LPJ_G0028166
 protein coding gene Chr4:44368093-44452032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028058
 protein coding gene Chr4:50521037-50601185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028706
 protein coding gene Chr4:43961212-44041346 (+)
PWK/PhJ MGP_PWKPhJ_G0027115
 protein coding gene Chr4:42694400-42770947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026943
 protein coding gene Chr4:43453984-43534634 (+)
WSB/EiJ MGP_WSBEiJ_G0027468
 protein coding gene Chr4:43862195-43944907 (+)



Homology
more
  • Human Ortholog
    TMOD1, tropomodulin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMOD1, tropomodulin 1
  • Synonyms
    D9S57E, ETMOD, TMOD
  • Links
    NCBI Gene ID: 7111
    neXtProt AC: NX_P28289
    UniProt: P28289

  • Chr Location
    9q22.33; chr9:97501180-97601743 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tmod1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in aborted heart development and consequent embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    91
  • cDNA Data
    11
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21916 NCBI Gene Model | MGI Sequence Detail 77093 C57BL/6J ±  kb
    transcript NM_021883 RefSeq | MGI Sequence Detail 2863 C57BL/6  
    polypeptide P49813 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15145
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 12
      Phenotypes 26
    • Earliest
      J:22833 Pilz A, et al., Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse. Genomics. 1995 Jan 1;25(1):139-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory