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Tpm1 Gene Detail
Summary
  • Symbol
    Tpm1
  • Name
    tropomyosin 1, alpha
  • Synonyms
    alpha-TM, TM2, Tm3, Tpm-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98809
    NCBI Gene: 22003
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66929872-66956688 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 36.27 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    621 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98809
 protein coding gene Chr9:66929872-66956954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034985
 protein coding gene Chr9:66904155-66930898 (-)
A/J MGP_AJ_G0034965
 protein coding gene Chr9:64592608-64619400 (-)
AKR/J MGP_AKRJ_G0034895
 protein coding gene Chr9:66129003-66155794 (-)
BALB/cJ MGP_BALBcJ_G0034958
 protein coding gene Chr9:64328555-64355335 (-)
C3H/HeJ MGP_C3HHeJ_G0034667
 protein coding gene Chr9:66667524-66694280 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035477
 protein coding gene Chr9:68732957-68759761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032388
 protein coding gene Chr9:64218441-64245174 (-)
CAST/EiJ MGP_CASTEiJ_G0033989
 protein coding gene Chr9:66891520-66919093 (-)
CBA/J MGP_CBAJ_G0034639
 protein coding gene Chr9:71098538-71125324 (-)
DBA/2J MGP_DBA2J_G0034798
 protein coding gene Chr9:64357904-64384692 (-)
FVB/NJ MGP_FVBNJ_G0034740
 protein coding gene Chr9:63703265-63731551 (-)
LP/J MGP_LPJ_G0034880
 protein coding gene Chr9:67179193-67205936 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034782
 protein coding gene Chr9:72307774-72336706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035499
 protein coding gene Chr9:66251333-66280610 (-)
PWK/PhJ MGP_PWKPhJ_G0033693
 protein coding gene Chr9:64588372-64615474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033526
 protein coding gene Chr9:66562435-66591205 (-)
WSB/EiJ MGP_WSBEiJ_G0034101
 protein coding gene Chr9:66143482-66170349 (-)



Homology
more
  • Human Ortholog
    TPM1, tropomyosin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPM1, tropomyosin 1
  • Synonyms
    C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA
  • Links
    NCBI Gene ID: 7168
    neXtProt AC: NX_P09493
    UniProt: P09493

  • Chr Location
    15q22.2; chr15:63042620-63071915 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tpm1 mouse models; 3 with human TPM1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 7 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    57
  • cDNA Data
    28
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032366 Ensembl Gene Model | MGI Sequence Detail 26817 C57BL/6J ±  kb
    transcript ENSMUST00000034928 Ensembl | MGI Sequence Detail 1824 Not Applicable  
    polypeptide ENSMUSP00000034928 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-15202, MGD-MRK-15205, MGI:2142971, MGI:2143162
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 43
      Diseases 5
      Gene Ontology 12
      Phenotypes 44
    • Earliest
      J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
    • Latest
      J:354186 Wilken MB, et al., Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis. Stem Cell Reports. 2024 Sep 10;19(9):1264-1276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory