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Tfrc Gene Detail
Summary
  • Symbol
    Tfrc
  • Name
    transferrin receptor
  • Synonyms
    2610028K12Rik, CD71, E430033M20Rik, Mtvr-1, Mtvr1, p90, TfR1, Trfr
  • Feature Type
    protein coding gene
  • IDs
    MGI:98822
    NCBI Gene: 22042
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32427738-32451612 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 23.06 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98822
 protein coding gene Chr16:32427714-32451612 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022742
 protein coding gene Chr16:30702623-30726429 (+)
A/J MGP_AJ_G0022707
 protein coding gene Chr16:29237284-29261055 (+)
AKR/J MGP_AKRJ_G0022680
 protein coding gene Chr16:30298314-30324158 (+)
BALB/cJ MGP_BALBcJ_G0022709
 protein coding gene Chr16:29384498-29408352 (+)
C3H/HeJ MGP_C3HHeJ_G0022474
 protein coding gene Chr16:30425023-30448874 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023158
 protein coding gene Chr16:31348308-31375753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020676
 protein coding gene Chr16:29613073-29637360 (+)
CAST/EiJ MGP_CASTEiJ_G0022002
 protein coding gene Chr16:30563217-30588576 (+)
CBA/J MGP_CBAJ_G0022444
 protein coding gene Chr16:32604530-32634261 (+)
DBA/2J MGP_DBA2J_G0022577
 protein coding gene Chr16:29082986-29107336 (+)
FVB/NJ MGP_FVBNJ_G0022552
 protein coding gene Chr16:29071515-29095349 (+)
LP/J MGP_LPJ_G0022644
 protein coding gene Chr16:30450351-30475363 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022571
 protein coding gene Chr16:32028725-32052454 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023170
 protein coding gene Chr16:30281471-30305314 (+)
PWK/PhJ MGP_PWKPhJ_G0021741
 protein coding gene Chr16:29410976-29435388 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021572
 protein coding gene Chr16:30079983-30103518 (+)
WSB/EiJ MGP_WSBEiJ_G0022046
 protein coding gene Chr16:30232004-30255718 (+)



Homology
more
  • Human Ortholog
    TFRC, transferrin receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFRC, transferrin receptor
  • Synonyms
    CD71, IMD46, p90, T9, TFR, TFR1, TR, TRFR
  • Links
    NCBI Gene ID: 7037
    neXtProt AC: NX_P02786
    UniProt: P02786

  • Chr Location
    3q29; chr3:196012511-196082153 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tfrc mouse models; 4 with human TFRC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 7 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant embryos do not survive past E12.5, exhibiting anemia, hydrops fetalis, and neurological defects. Haploinsufficiency results in abnromal erythrocytes and tissue iron deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    43
  • cDNA Data
    311
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022797 Ensembl Gene Model | MGI Sequence Detail 23875 C57BL/6J ±  kb
    transcript ENSMUST00000023486 Ensembl | MGI Sequence Detail 4890 Not Applicable  
    polypeptide ENSMUSP00000023486 Ensembl | MGI Sequence Detail 763 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001945 transferrin receptor protein 1
      (term hierarchy)
    • InterPro Domains
      IPR003137 PA domain
      IPR046450 PA domain superfamily
      IPR007484 Peptidase M28
      IPR007365 Transferrin receptor-like, dimerisation domain
      IPR036757 Transferrin receptor-like, dimerisation domain superfamily
      IPR037324 Transferrin receptor protein 1/2, PA domain
      IPR039373 Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
    • GlyGen
      Q62351 6 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 318
      cDNA 312
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-12700, MGD-MRK-12701, MGD-MRK-15225, MGI:1923611, MGI:2146387, MGI:2146425, MGI:2146541, MGI:2442494, MGI:97229
    References
    more
    • Summaries
      All 197
      Developmental Gene Expression 50
      Diseases 1
      Gene Ontology 39
      Phenotypes 49
    • Earliest
      J:30966 Trowbridge IS, et al., Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody. J Cell Physiol. 1982 Sep;112(3):403-10
    • Latest
      J:346744 Zhang Y, et al., Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders. Cell Rep. 2024 Mar 26;43(3):113900
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory