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Trp53 Gene Detail
Summary
  • Symbol
    Trp53
  • Name
    transformation related protein 53
  • Synonyms
    p44, p53
  • Feature Type
    protein coding gene
  • IDs
    MGI:98834
    NCBI Gene: 22059
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69471185-69482699 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.83 cM, cytoband B2-C
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98834
 protein coding gene Chr11:69471174-69482699 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018538
 protein coding gene Chr11:70027960-70039649 (+)
A/J MGP_AJ_G0018506
 protein coding gene Chr11:67392058-67403485 (+)
AKR/J MGP_AKRJ_G0018475
 protein coding gene Chr11:69403123-69414826 (+)
BALB/cJ MGP_BALBcJ_G0018478
 protein coding gene Chr11:67703718-67715696 (+)
C3H/HeJ MGP_C3HHeJ_G0018291
 protein coding gene Chr11:69422865-69433891 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018929
 protein coding gene Chr11:72152489-72164199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016574
 protein coding gene Chr11:64316396-64328040 (+)
CAST/EiJ MGP_CASTEiJ_G0017846
 protein coding gene Chr11:69667927-69678925 (+)
CBA/J MGP_CBAJ_G0018264
 protein coding gene Chr11:75374993-75386032 (+)
DBA/2J MGP_DBA2J_G0018373
 protein coding gene Chr11:66975223-66986658 (+)
FVB/NJ MGP_FVBNJ_G0018363
 protein coding gene Chr11:66612015-66623557 (+)
LP/J MGP_LPJ_G0018443
 protein coding gene Chr11:70599323-70610973 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018386
 protein coding gene Chr11:75977243-75989726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018971
 protein coding gene Chr11:69656893-69668367 (+)
PWK/PhJ MGP_PWKPhJ_G0017620
 protein coding gene Chr11:67624324-67635362 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017410
 protein coding gene Chr11:69474556-69485483 (+)
WSB/EiJ MGP_WSBEiJ_G0017900
 protein coding gene Chr11:69330183-69344422 (+)



Homology
more
  • Human Ortholog
    TP53, tumor protein p53
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP53, tumor protein p53
  • Synonyms
    BCC7, BMFS5, LFS1, P53, TRP53
  • Links
    NCBI Gene ID: 7157
    neXtProt AC: NX_P04637
    UniProt: P04637

  • Chr Location
    17p13.1; chr17:7661779-7687546 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with Trp53 mouse models; 38 with human TP53 associations

Human Disease Mouse Models
      
IDs
 View 14 models
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    18 with disease annotations
  • References
    93 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    314 phenotypes from 75 alleles in 88 genetic backgrounds
    564 phenotypes from multigenic genotypes
    14 images
    3618 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus affect cell-cycle regulation and apoptosis. Null homozygotes show high, early-onset tumor incidence; some have persistent hyaloid vasculature and cataracts. Truncated or temperature-sensitive alleles cause early aging phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    411
  • GO References
    160
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1656
  • Tissues
    403
  • cDNA Data
    131
  • Literature Summary
    371
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059552 Ensembl Gene Model | MGI Sequence Detail 11515 C57BL/6J ±  kb
    transcript ENSMUST00000108658 Ensembl | MGI Sequence Detail 1771 Not Applicable  
    polypeptide ENSMUSP00000104298 Ensembl | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      Genomic 15
      cDNA 140
      Primer pair 33
      Other 9

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-15247, MGI:3584375, MGI:3584378, MGI:3584379
    References
    more
    • Summaries
      All 4997
      Developmental Gene Expression 371
      Diseases 93
      Gene Ontology 160
      Phenotypes 3618
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357848 Cunha AF, et al., Trp53 Deletion Promotes Exacerbated Colitis, Facilitates Lgr5+ Cancer Stem Cell Expansion, and Fuels Tumorigenesis in AOM/DSS-Induced Colorectal Cancer. Int J Mol Sci. 2024 Oct 11;25(20)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory