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Vcl Gene Detail
Summary
  • Symbol
    Vcl
  • Name
    vinculin
  • Synonyms
    metavinculin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98927
    NCBI Gene: 22330
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20979466-21083744 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2293 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98927
 protein coding gene Chr14:20979436-21083744 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021049
 protein coding gene Chr14:13731157-13834111 (+)
A/J MGP_AJ_G0020998
 protein coding gene Chr14:13386233-13491651 (+)
AKR/J MGP_AKRJ_G0020975
 protein coding gene Chr14:13920539-14025987 (+)
BALB/cJ MGP_BALBcJ_G0021001
 protein coding gene Chr14:13495179-13594946 (+)
C3H/HeJ MGP_C3HHeJ_G0020785
 protein coding gene Chr14:13862739-13965630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021434
 protein coding gene Chr14:14210632-14313535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019002
 protein coding gene Chr14:13702409-13799287 (+)
CAST/EiJ MGP_CASTEiJ_G0020309
 protein coding gene Chr14:13647138-13746891 (+)
CBA/J MGP_CBAJ_G0020751
 protein coding gene Chr14:14937190-15048880 (+)
DBA/2J MGP_DBA2J_G0020874
 protein coding gene Chr14:13212961-13317534 (+)
FVB/NJ MGP_FVBNJ_G0020857
 protein coding gene Chr14:13105370-13206638 (+)
LP/J MGP_LPJ_G0020950
 protein coding gene Chr14:13938417-14047899 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020883
 protein coding gene Chr14:14699013-14812757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021467
 protein coding gene Chr14:13709722-13816861 (+)
PWK/PhJ MGP_PWKPhJ_G0020058
 protein coding gene Chr14:12784628-12893512 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019880
 protein coding gene Chr14:13504265-13611123 (+)
WSB/EiJ MGP_WSBEiJ_G0020365
 protein coding gene Chr14:13696636-13802202 (+)



Homology
more
  • Human Ortholog
    VCL, vinculin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCL, vinculin
  • Synonyms
    CMD1W, CMH15, HEL114, MV, MVCL, VINC
  • Links
    NCBI Gene ID: 7414
    neXtProt AC: NX_P18206
    UniProt: P18206

  • Chr Location
    10q22.2; chr10:73995193-74121363 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human VCL associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    92
  • cDNA Data
    136
  • Literature Summary
    103
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021823 Ensembl Gene Model | MGI Sequence Detail 104279 C57BL/6J ±  kb
    transcript ENSMUST00000022369 Ensembl | MGI Sequence Detail 5267 Not Applicable  
    polypeptide ENSMUSP00000022369 Ensembl | MGI Sequence Detail 1066 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 146
      Genomic 1
      cDNA 136
      Primer pair 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 103
      Gene Ontology 33
      Phenotypes 20
    • Earliest
      J:10655 Weller PA, et al., Complete sequence of human vinculin and assignment of the gene to chromosome 10. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory