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Vil1 Gene Detail
Summary
  • Symbol
    Vil1
  • Name
    villin 1
  • Synonyms
    Villin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98930
    NCBI Gene: 22349
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74448543-74474719 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C5
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98930
 protein coding gene Chr1:74448535-74474719 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016151
 protein coding gene Chr1:75008415-75034543 (+)
A/J MGP_AJ_G0016134
 protein coding gene Chr1:72379776-72408221 (+)
AKR/J MGP_AKRJ_G0016091
 protein coding gene Chr1:74394767-74421130 (+)
BALB/cJ MGP_BALBcJ_G0016089
 protein coding gene Chr1:72449154-72475367 (+)
C3H/HeJ MGP_C3HHeJ_G0015920
 protein coding gene Chr1:74725000-74755879 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016542
 protein coding gene Chr1:77925307-77956910 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014263
 protein coding gene Chr1:67968434-67994741 (+)
CAST/EiJ MGP_CASTEiJ_G0015504
 protein coding gene Chr1:74056427-74084112 (+)
CBA/J MGP_CBAJ_G0015893
 protein coding gene Chr1:80454497-80484505 (+)
DBA/2J MGP_DBA2J_G0015994
 protein coding gene Chr1:71716051-71742642 (+)
FVB/NJ MGP_FVBNJ_G0015997
 protein coding gene Chr1:70895166-70924518 (+)
LP/J MGP_LPJ_G0016066
 protein coding gene Chr1:76115365-76143663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016017
 protein coding gene Chr1:83871609-83898217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016589
 protein coding gene Chr1:74461257-74490087 (+)
PWK/PhJ MGP_PWKPhJ_G0015291
 protein coding gene Chr1:71169861-71196520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015069
 protein coding gene Chr1:73833205-73860585 (+)
WSB/EiJ MGP_WSBEiJ_G0015566
 protein coding gene Chr1:74257925-74285355 (+)



Homology
more
  • Human Ortholog
    VIL1, villin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIL1, villin 1
  • Synonyms
    D2S1471, VIL
  • Links
    NCBI Gene ID: 7429
    neXtProt AC: NX_P09327
    UniProt: P09327

  • Chr Location
    2q35; chr2:218419121-218453295 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants do not exhibit gross abnormalities or apparent defects of microvilli morphogenesis, however in one line, an increased sensitivity to colitis induced by dextran sulfate was observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    125
  • cDNA Data
    12
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22349 NCBI Gene Model | MGI Sequence Detail 26177 C57BL/6J ±  kb
    transcript NM_009509 RefSeq | MGI Sequence Detail 3117 ZRU/MplStud  
    polypeptide Q62468 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 16
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15393
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 49
      Gene Ontology 13
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358604 Mulet I, et al., TET3 regulates terminal cell differentiation at the metabolic level. Nat Commun. 2024 Nov 18;15(1):9749
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory