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Arf6 Gene Detail
Summary
  • Symbol
    Arf6
  • Name
    ARF GTPase 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99435
    NCBI Gene: 11845
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69418924-69420557 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99435
 protein coding gene Chr12:69418924-69422754 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019796
 protein coding gene Chr12:69062005-69065835 (+)
A/J MGP_AJ_G0019754
 protein coding gene Chr12:66492298-66496128 (+)
AKR/J MGP_AKRJ_G0019730
 protein coding gene Chr12:68482086-68485916 (+)
BALB/cJ MGP_BALBcJ_G0019734
 protein coding gene Chr12:66952302-66956132 (+)
C3H/HeJ MGP_C3HHeJ_G0019540
 protein coding gene Chr12:68946346-68950951 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020186
 protein coding gene Chr12:71244029-71247858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017806
 protein coding gene Chr12:64036015-64039823 (+)
CAST/EiJ MGP_CASTEiJ_G0019091
 protein coding gene Chr12:63704653-63723697 (+)
CBA/J MGP_CBAJ_G0019509
 protein coding gene Chr12:73900282-73904112 (+)
DBA/2J MGP_DBA2J_G0019625
 protein coding gene Chr12:66401163-66404992 (+)
FVB/NJ MGP_FVBNJ_G0019612
 protein coding gene Chr12:65299544-65303374 (+)
LP/J MGP_LPJ_G0019697
 protein coding gene Chr12:69015342-69019156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019651
 protein coding gene Chr12:77235101-77238931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020221
 protein coding gene Chr12:67954528-67958358 (+)
PWK/PhJ MGP_PWKPhJ_G0018856
 protein coding gene Chr12:60670603-60688562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018651
 protein coding gene Chr12:62349409-62353229 (+)
WSB/EiJ MGP_WSBEiJ_G0019142
 protein coding gene Chr12:68570478-68574308 (+)



Homology
more
  • Human Ortholog
    ARF6, ARF GTPase 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARF6, ARF GTPase 6
  • Links
    NCBI Gene ID: 382
    neXtProt AC: NX_P62330
    UniProt: P62330

  • Chr Location
    14q21.3; chr14:49893079-49897054 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic and perinatal lethality beginning around mid-gestation, impaired liver development, and edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    225
  • cDNA Data
    106
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044147 Ensembl Gene Model | MGI Sequence Detail 1634 C57BL/6J ±  kb
    transcript ENSMUST00000050063 Ensembl | MGI Sequence Detail 1534 Not Applicable  
    polypeptide ENSMUSP00000055862 Ensembl | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 111
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16199, MGI:2144883, MGI:2145032
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 17
      Gene Ontology 21
      Phenotypes 25
    • Earliest
      J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
    • Latest
      J:352960 Wee Y, et al., Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy. Nat Commun. 2024 Aug 4;15(1):6613
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory