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Ptgir Gene Detail
Summary
  • Symbol
    Ptgir
  • Name
    prostaglandin I receptor (IP)
  • Synonyms
    IP, prostacyclin receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:99535
    NCBI Gene: 19222
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16640442-16644828 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99535
 protein coding gene Chr7:16640415-16644830 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031722
 protein coding gene Chr7:14673559-14677970 (+)
A/J MGP_AJ_G0031694
 protein coding gene Chr7:14387671-14392086 (+)
AKR/J MGP_AKRJ_G0031619
 protein coding gene Chr7:14729158-14733573 (+)
BALB/cJ MGP_BALBcJ_G0031701
 protein coding gene Chr7:14495581-14499996 (+)
C3H/HeJ MGP_C3HHeJ_G0031423
 protein coding gene Chr7:14913513-14917924 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032167
 protein coding gene Chr7:15402254-15406669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029246
 protein coding gene Chr7:15924193-15928566 (+)
CAST/EiJ MGP_CASTEiJ_G0030774
 protein coding gene Chr7:11689050-11693466 (+)
CBA/J MGP_CBAJ_G0031382
 protein coding gene Chr7:15918999-15923410 (+)
DBA/2J MGP_DBA2J_G0031538
 protein coding gene Chr7:14279538-14283953 (+)
FVB/NJ MGP_FVBNJ_G0031494
 protein coding gene Chr7:14179980-14184395 (+)
LP/J MGP_LPJ_G0031623
 protein coding gene Chr7:14908839-14913250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031529
 protein coding gene Chr7:15838776-15843191 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032196
 protein coding gene Chr7:14507192-14511607 (+)
PWK/PhJ MGP_PWKPhJ_G0030498
 protein coding gene Chr7:11799654-11804065 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030325
 protein coding gene Chr7:9429751-9434140 (+)
WSB/EiJ MGP_WSBEiJ_G0030871
 protein coding gene Chr7:14574015-14578430 (+)



Homology
more
  • Human Ortholog
    PTGIR, prostaglandin I2 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGIR, prostaglandin I2 receptor
  • Synonyms
    IP, PRIPR
  • Links
    NCBI Gene ID: 5739
    neXtProt AC: NX_P43119
    UniProt: P43119

  • Chr Location
    19q13.32; chr19:46610687-46625089 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased susceptibility to thrombosis and injury-induced vascular proliferation, and decreased inflammatory and pain responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    45
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19222 NCBI Gene Model | MGI Sequence Detail 4387 C57BL/6J ±  kb
    transcript NM_008967 RefSeq | MGI Sequence Detail 3305 ZRU/MplStud  
    polypeptide P43252 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16313
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:17520 Namba T, et al., cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem. 1994 Apr 1;269(13):9986-92
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory