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Iglc2 Gene Detail
Summary
  • Symbol
    Iglc2
  • Name
    immunoglobulin lambda constant 2
  • Feature Type
    gene segment
  • IDs
    MGI:99547
    NCBI Gene: 110786
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr16:19017286-19017602 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.89 cM
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99547
 gene segment Chr16:19017146-19019101 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000014
 gene segment Chr16:16478888-16480843 (-)
A/J MGP_AJ_G0000014
 gene segment Chr16:15655895-15657850 (-)
AKR/J MGP_AKRJ_G0000013
 gene segment Chr16:16285112-16287067 (-)
BALB/cJ MGP_BALBcJ_G0000014
 gene segment Chr16:15820756-15822711 (-)
C3H/HeJ MGP_C3HHeJ_G0000014
 gene segment Chr16:16448056-16450011 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000014
 gene segment Chr16:16779667-16781622 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0000014
 gene segment Chr16:17516074-17518029 (-)
DBA/2J MGP_DBA2J_G0000014
 gene segment Chr16:15552969-15554924 (-)
FVB/NJ MGP_FVBNJ_G0000014
 gene segment Chr16:15639471-15641426 (-)
LP/J MGP_LPJ_G0000014
 gene segment Chr16:16223622-16225577 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000013
 gene segment Chr16:17127338-17129293 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000014
 gene segment Chr16:16202106-16204061 (-)
PWK/PhJ MGP_PWKPhJ_G0000013
 gene segment Chr16:15833339-15835360 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0000014
 gene segment Chr16:16237202-16239137 (-)



Homology
more
  • Human Ortholog
    IGLC2, immunoglobulin lambda constant 2
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGLC2, immunoglobulin lambda constant 2
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3538
    UniProt: P0DOY2

  • Chr Location
    22q11.22; chr22:22900976-22901437 (+)  GRCh38
  • Human Ortholog
    IGLC3, immunoglobulin lambda constant 3 (Kern-Oz+ marker)
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3539
    UniProt: P0DOY3

  • Chr Location
    22q11.22; chr22:22906342-22906803 (+)  GRCh38
  • Human Ortholog
    IGLC6, immunoglobulin lambda constant 6
  • Synonyms
    IGLC
  • Links
    NCBI Gene ID: 3542
    UniProt: P0CF74

  • Chr Location
    22q11.22; chr22:22919535-22919858 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 110786 NCBI Gene Model | MGI Sequence Detail 317 C57BL/6J ±  kb
polypeptide P01844 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • PDB
    2QHR
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR050160 Major Histocompatibility Complex/Immunoglobulin
Molecular
Reagents
less
  • All nucleic 23
    Genomic 13
    cDNA 10
Other
Accession IDs
less
MGD-MRK-16325
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:20060 Bernard O, et al., Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell. 1978 Dec;15(4):1133-44
  • Latest
    J:151668 Matheson LS, et al., Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching. Int Immunol. 2009 Aug;21(8):957-66
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory