| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
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IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr143629 | Chr17:31120532-31120542 (+) | -304 bp |
| Tssr143630 | Chr17:31120785-31120800 (+) | -48 bp |
| Tssr5066 | Chr17:31120817-31120820 (+) | -22 bp |
| Tssr143631 | Chr17:31138557-31138589 (+) | 17,732 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Kcal2 | Chr17, syntenic | Chr17:26401012-52911704 | J:117468 | Previously identified QTLs Mnic1 (macronutrient intake, carbohydrate 1) and Kcal2 (kilocalorie 2) at 20 cM on mouse Chromosome 17 were confirmed by analysis of speed congenic lines. B6.CAST- (D17Mit19-D17Mit91) carries a 38 cM region of CAST/EiJ-derived DNA from D17Mit19 (3 cM; 4.7 Mb) to D17Mit91 (37.8 cM; 63.5 Mb) on a C57BL/6J genetic background. The congenic interval contains Mnic1 and Kcal2. Donor strain CAST/EiJ displays significantly higher total daily caloric intake compared to background strain C57BL/6J. Likewise, congenic line B6.CAST-(D17Mit19-D17Mit91) displays 17% higher total calorie intake compared to C57BL/6J and prefers a carbohydrate diet (27% increase) over a fat diet. Glp1r at 18 cM is a positional candidate gene for Kcal2. Glp1r exhibits decreased expression in the hypothalamus and antral stomach, and increased expression in the pancreas, of CAST/EiJ mice compared to C57BL/6J mice. In B6.CAST- (D17Mit19-D17Mit91) mice, Glp1r expression is increased in the pancreas and decreased in the stomach compared to C57BL/6J mice. Sequence analysis of Glp1r revealed 3 polymorphisms between CAST/EiJ and C57BL/6J, one of which results in an amino acid substitution in exon 13 (C416Y). Glo1 at 16 cM is a positional candidate gene for Mnic1. Glo1 exhibits increased expression in liver and hypothalamus of congenic mice compared to C57BL/6J. Sequence analysis of Glo1 detected one silent polymorphism between CAST/EiJ and C57BL/6J. Other potential candidate genes mapping to the congenic interval include Clps (13.1 cM), Ppard (13.5 cM), and Apom. |
| Mnic1 | Chr17, syntenic | Chr17:4854752-45670266 | J:117468 | Previously identified QTLs Mnic1 (macronutrient intake, carbohydrate 1) and Kcal2 (kilocalorie 2) at 20 cM on mouse Chromosome 17 were confirmed by analysis of speed congenic lines. B6.CAST- (D17Mit19-D17Mit91) carries a 38 cM region of CAST/EiJ-derived DNA from D17Mit19 (3 cM; 4.7 Mb) to D17Mit91 (37.8 cM; 63.5 Mb) on a C57BL/6J genetic background. The congenic interval contains Mnic1 and Kcal2. Donor strain CAST/EiJ displays significantly higher total daily caloric intake compared to background strain C57BL/6J. Likewise, congenic line B6.CAST-(D17Mit19-D17Mit91) displays 17% higher total calorie intake compared to C57BL/6J and prefers a carbohydrate diet (27% increase) over a fat diet. Glp1r at 18 cM is a positional candidate gene for Kcal2. Glp1r exhibits decreased expression in the hypothalamus and antral stomach, and increased expression in the pancreas, of CAST/EiJ mice compared to C57BL/6J mice. In B6.CAST- (D17Mit19-D17Mit91) mice, Glp1r expression is increased in the pancreas and decreased in the stomach compared to C57BL/6J mice. Sequence analysis of Glp1r revealed 3 polymorphisms between CAST/EiJ and C57BL/6J, one of which results in an amino acid substitution in exon 13 (C416Y). Glo1 at 16 cM is a positional candidate gene for Mnic1. Glo1 exhibits increased expression in liver and hypothalamus of congenic mice compared to C57BL/6J. Sequence analysis of Glo1 detected one silent polymorphism between CAST/EiJ and C57BL/6J. Other potential candidate genes mapping to the congenic interval include Clps (13.1 cM), Ppard (13.5 cM), and Apom. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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