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Gcgr Gene Detail
Summary
  • Symbol
    Gcgr
  • Name
    glucagon receptor
  • Synonyms
    GR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99572
    NCBI Gene: 14527
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120421525-120429812 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.24 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99572
 protein coding gene Chr11:120420011-120429815 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019507
 protein coding gene Chr11:124999847-125008134 (+)
A/J MGP_AJ_G0019475
 protein coding gene Chr11:119438959-119447246 (+)
AKR/J MGP_AKRJ_G0019445
 protein coding gene Chr11:123033459-123041746 (+)
BALB/cJ MGP_BALBcJ_G0019450
 protein coding gene Chr11:119795133-119803420 (+)
C3H/HeJ MGP_C3HHeJ_G0019256
 protein coding gene Chr11:123370292-123378579 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019898
 protein coding gene Chr11:128780740-128789027 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017524
 protein coding gene Chr11:116431227-116439422 (+)
CAST/EiJ MGP_CASTEiJ_G0018810
 protein coding gene Chr11:124861565-124873441 (+)
CBA/J MGP_CBAJ_G0019227
 protein coding gene Chr11:133824468-133832755 (+)
DBA/2J MGP_DBA2J_G0019339
 protein coding gene Chr11:118809165-118817452 (+)
FVB/NJ MGP_FVBNJ_G0019331
 protein coding gene Chr11:118519231-118527518 (+)
LP/J MGP_LPJ_G0019411
 protein coding gene Chr11:125303753-125312040 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019364
 protein coding gene Chr11:132659101-132667388 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019938
 protein coding gene Chr11:123720960-123729247 (+)
PWK/PhJ MGP_PWKPhJ_G0018576
 protein coding gene Chr11:120242211-120254256 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018368
 protein coding gene Chr11:123482710-123494182 (+)
WSB/EiJ MGP_WSBEiJ_G0018862
 protein coding gene Chr11:123709131-123717418 (+)



Homology
more
  • Human Ortholog
    GCGR, glucagon receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCGR, glucagon receptor
  • Synonyms
    GGR, GL-R, MVAH
  • Links
    NCBI Gene ID: 2642
    neXtProt AC: NX_P47871
    UniProt: P47871

  • Chr Location
    17q25.3; chr17:81804132-81814008 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gcgr mouse models; 2 with human GCGR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 7 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    3 images
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon and amino acid levels associated with alpha-cell hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    27
  • cDNA Data
    26
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025127 Ensembl Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
    transcript ENSMUST00000026119 Ensembl | MGI Sequence Detail 1957 Not Applicable  
    polypeptide ENSMUSP00000026119 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007892 glucagon receptor
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
      IPR003291 GPCR, family 2, glucagon receptor
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q61606 5 sites
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 27
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16353
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 10
      Phenotypes 82
    • Earliest
      J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory