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Defa6 Gene Detail
Summary
  • Symbol
    Defa6
  • Name
    defensin, alpha, 6
  • Synonyms
    Defcr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99582
    NCBI Gene: 13240
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22223899-22224507 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99582
 protein coding gene Chr8:22223899-22224507 (.)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Synonyms
    DEF1, DEFA2, HNP-1, HP-1, HP1, MRS
  • Links
    NCBI Gene ID: 1667
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6977649-6980092 (-)  GRCh38
  • Human Ortholog
    DEFA1B, defensin alpha 1B
  • Synonyms
    HNP-1, HP-1, HP1
  • Links
    NCBI Gene ID: 728358
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6996766-6999198 (-)  GRCh38
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Synonyms
    DEF3, HNP-3, HNP3, HP-3, HP3
  • Links
    NCBI Gene ID: 1668
    neXtProt AC: NX_P59666
    UniProt: P59666

  • Chr Location
    8p23.1; chr8:7015869-7018297 (-)  GRCh38
  • Human Ortholog
    DEFA5, defensin alpha 5
  • Synonyms
    DEF5, HD-5
  • Links
    NCBI Gene ID: 1670
    neXtProt AC: NX_Q01523
    UniProt: Q01523

  • Chr Location
    8p23.1; chr8:7055304-7056739 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    neXtProt AC: NX_Q01524
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    2
  • Literature Summary
    4
  • Other Mouse Links
    GEO
Sequences &
Gene Models
less
  • All Sequences
    7
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic AF178041 GenBank | ENA | DDBJ | MGI Sequence Detail 617 129X1/SvJ ±  kb
transcript NM_007852 RefSeq | MGI Sequence Detail 282 129  
polypeptide P50704 UniProt | EBI | MGI Sequence Detail 93 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    Genomic 1
    cDNA 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16364
References
more
  • Summaries
    All 19
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:16918 Huttner KM, et al., Structure and diversity of the murine cryptdin gene family. Genomics. 1994 Feb;19(3):448-53
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory