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Epha3 Gene Detail
Summary
  • Symbol
    Epha3
  • Name
    Eph receptor A3
  • Synonyms
    Cek4, End3, Hek, Hek4, Mek4, Tyro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99612
    NCBI Gene: 13837
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:63363897-63684538 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 36.49 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99612
 protein coding gene Chr16:63363895-63684538 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022938
 protein coding gene Chr16:62990802-63325086 (-)
A/J MGP_AJ_G0022906
 protein coding gene Chr16:60298639-60619177 (-)
AKR/J MGP_AKRJ_G0022876
 protein coding gene Chr16:62175780-62503628 (-)
BALB/cJ MGP_BALBcJ_G0022908
 protein coding gene Chr16:60486299-60811765 (-)
C3H/HeJ MGP_C3HHeJ_G0022670
 protein coding gene Chr16:62470662-62795996 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023356
 protein coding gene Chr16:64865403-65212209 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020859
 protein coding gene Chr16:59437406-59741994 (-)
CAST/EiJ MGP_CASTEiJ_G0022194
 protein coding gene Chr16:62698192-63040962 (-)
CBA/J MGP_CBAJ_G0022641
 protein coding gene Chr16:67567390-67932999 (-)
DBA/2J MGP_DBA2J_G0022773
 protein coding gene Chr16:60067484-60389057 (-)
FVB/NJ MGP_FVBNJ_G0022747
 protein coding gene Chr16:59695653-60011363 (-)
LP/J MGP_LPJ_G0022842
 protein coding gene Chr16:62793360-63143291 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022766
 protein coding gene Chr16:68648891-69097857 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023372
 protein coding gene Chr16:62252251-62587051 (-)
PWK/PhJ MGP_PWKPhJ_G0021936
 protein coding gene Chr16:60244995-60568766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021766
 protein coding gene Chr16:61989742-62315394 (-)
WSB/EiJ MGP_WSBEiJ_G0022240
 protein coding gene Chr16:62323700-62664547 (-)



Homology
more
  • Human Ortholog
    EPHA3, EPH receptor A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA3, EPH receptor A3
  • Synonyms
    EK4, ETK, ETK1, HEK, HEK4, TYRO4
  • Links
    NCBI Gene ID: 2042
    neXtProt AC: NX_P29320
    UniProt: P29320

  • Chr Location
    3p11.1; chr3:89107621-89482134 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EPHA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1577
  • Tissues
    390
  • cDNA Data
    90
  • Literature Summary
    95
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052504 Ensembl Gene Model | MGI Sequence Detail 320642 C57BL/6J ±  kb
    transcript ENSMUST00000064405 Ensembl | MGI Sequence Detail 5663 Not Applicable  
    polypeptide ENSMUSP00000066554 Ensembl | MGI Sequence Detail 984 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007123 ephrin type-A receptor 3
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR034266 Ephrin type-A receptor 3, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      P29319 5 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 113
      Genomic 1
      cDNA 93
      Primer pair 13
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16397, MGI:2146641, MGI:2662731
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 95
      Gene Ontology 17
      Phenotypes 15
    • Earliest
      J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
    • Latest
      J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory