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Syt1 Gene Detail
Summary
  • Symbol
    Syt1
  • Name
    synaptotagmin I
  • Synonyms
    G630098F17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99667
    NCBI Gene: 20979
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:108333511-108846843 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 56.52 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14160 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99667
 protein coding gene Chr10:108333511-108846852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017714
 protein coding gene Chr10:110748647-111292972 (-)
A/J MGP_AJ_G0017691
 protein coding gene Chr10:106587375-107110355 (-)
AKR/J MGP_AKRJ_G0017653
 protein coding gene Chr10:109692766-110225514 (-)
BALB/cJ MGP_BALBcJ_G0017655
 protein coding gene Chr10:106980537-107497782 (-)
C3H/HeJ MGP_C3HHeJ_G0017480
 protein coding gene Chr10:109802934-110341954 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018112
 protein coding gene Chr10:114597694-115137260 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015791
 protein coding gene Chr10:101492576-101999969 (-)
CAST/EiJ MGP_CASTEiJ_G0017041
 protein coding gene Chr10:109901016-110468000 (-)
CBA/J MGP_CBAJ_G0017449
 protein coding gene Chr10:119067683-119616601 (-)
DBA/2J MGP_DBA2J_G0017554
 protein coding gene Chr10:105724888-106241291 (-)
FVB/NJ MGP_FVBNJ_G0017548
 protein coding gene Chr10:104716041-105229968 (-)
LP/J MGP_LPJ_G0017628
 protein coding gene Chr10:111379805-111921103 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017577
 protein coding gene Chr10:121652986-122230028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018150
 protein coding gene Chr10:109692161-110222842 (-)
PWK/PhJ MGP_PWKPhJ_G0016823
 protein coding gene Chr10:105788560-106328249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016613
 protein coding gene Chr10:108456724-109028515 (-)
WSB/EiJ MGP_WSBEiJ_G0017101
 protein coding gene Chr10:109829209-110372341 (-)



Homology
more
  • Human Ortholog
    SYT1, synaptotagmin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYT1, synaptotagmin 1
  • Synonyms
    BAGOS, P65, SVP65, SYT
  • Links
    NCBI Gene ID: 6857
    neXtProt AC: NX_P21579
    UniProt: P21579

  • Chr Location
    12q21.2; chr12:78863982-79452008 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice do not suckle, show impaired synaptic transmission and Ca2+-evoked neurotransmitter release, and die by 48 hrs of life. Knock-in mice bearing a missense mutation show enhanced synaptic depression while those carrying a point mutationshow reduced synaptic release probability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1425
  • Tissues
    178
  • cDNA Data
    19
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035864 Ensembl Gene Model | MGI Sequence Detail 513333 C57BL/6J ±  kb
    transcript ENSMUST00000064054 Ensembl | MGI Sequence Detail 4745 Not Applicable  
    polypeptide ENSMUSP00000063293 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 2
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-16452, MGI:2143817
    References
    more
    • Summaries
      All 204
      Developmental Gene Expression 38
      Gene Ontology 36
      Phenotypes 75
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory