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Clock Gene Detail
Summary
  • Symbol
    Clock
  • Name
    clock circadian regulator
  • Synonyms
    5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
  • Feature Type
    protein coding gene
  • IDs
    MGI:99698
    NCBI Gene: 12753
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76357715-76452639 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 40.63 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1460 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99698
 protein coding gene Chr5:76357715-76452675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029642
 protein coding gene Chr5:76386417-76476727 (-)
A/J MGP_AJ_G0029610
 protein coding gene Chr5:73462202-73554581 (-)
AKR/J MGP_AKRJ_G0029558
 protein coding gene Chr5:75850793-75950769 (-)
BALB/cJ MGP_BALBcJ_G0029619
 protein coding gene Chr5:74206978-74302693 (-)
C3H/HeJ MGP_C3HHeJ_G0029342
 protein coding gene Chr5:76240312-76333710 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030073
 protein coding gene Chr5:79449078-79538913 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027314
 protein coding gene Chr5:69125168-69207568 (-)
CAST/EiJ MGP_CASTEiJ_G0028750
 protein coding gene Chr5:75421467-75513468 (-)
CBA/J MGP_CBAJ_G0029311
 protein coding gene Chr5:82035080-82141119 (-)
DBA/2J MGP_DBA2J_G0029456
 protein coding gene Chr5:73543181-73630621 (-)
FVB/NJ MGP_FVBNJ_G0029417
 protein coding gene Chr5:72717872-72813599 (-)
LP/J MGP_LPJ_G0029543
 protein coding gene Chr5:76827213-76917066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029445
 protein coding gene Chr5:85220191-85323286 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030106
 protein coding gene Chr5:75417920-75507215 (-)
PWK/PhJ MGP_PWKPhJ_G0028473
 protein coding gene Chr5:72546476-72636805 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028308
 protein coding gene Chr5:74782742-74865298 (-)
WSB/EiJ MGP_WSBEiJ_G0028830
 protein coding gene Chr5:75725726-75814236 (-)



Homology
more
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLOCK, clock circadian regulator
  • Synonyms
    bHLHe8, KAT13D
  • Links
    NCBI Gene ID: 9575
    neXtProt AC: NX_O15516
    UniProt: O15516

  • Chr Location
    4q12; chr4:55427903-55546909 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Clock mouse models; 2 with human CLOCK associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 7 alleles in 16 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    220 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    135
  • GO References
    77
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1088
  • Tissues
    194
  • cDNA Data
    25
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029238 Ensembl Gene Model | MGI Sequence Detail 94925 C57BL/6J ±  kb
    transcript ENSMUST00000202651 Ensembl | MGI Sequence Detail 9744 Not Applicable  
    polypeptide ENSMUSP00000143939 Ensembl | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 10
      cDNA 25
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16483, MGI:2442107
    References
    more
    • Summaries
      All 384
      Developmental Gene Expression 20
      Diseases 3
      Gene Ontology 77
      Phenotypes 220
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:349795 Peng F, et al., Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis. Cell Metab. 2024 May 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory