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Nt5e Gene Detail
Summary
  • Symbol
    Nt5e
  • Name
    5' nucleotidase, ecto
  • Synonyms
    2210401F01Rik, CD73, ecto-5'-nucleotidase, Nt5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99782
    NCBI Gene: 23959
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:88209662-88254142 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.24 cM, cytoband E3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99782
 protein coding gene Chr9:88209250-88254145 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035106
 protein coding gene Chr9:89198018-89244813 (+)
A/J MGP_AJ_G0035087
 protein coding gene Chr9:86085828-86131449 (+)
AKR/J MGP_AKRJ_G0035015
 protein coding gene Chr9:88096951-88142452 (+)
BALB/cJ MGP_BALBcJ_G0035075
 protein coding gene Chr9:85700626-85745406 (+)
C3H/HeJ MGP_C3HHeJ_G0034787
 protein coding gene Chr9:88571536-88617598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035599
 protein coding gene Chr9:91609850-91655545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032506
 protein coding gene Chr9:84780521-84826137 (+)
CAST/EiJ MGP_CASTEiJ_G0034105
 protein coding gene Chr9:89016725-89078297 (+)
CBA/J MGP_CBAJ_G0034760
 protein coding gene Chr9:94812414-94861724 (+)
DBA/2J MGP_DBA2J_G0034918
 protein coding gene Chr9:85608690-85657101 (+)
FVB/NJ MGP_FVBNJ_G0034861
 protein coding gene Chr9:84663184-84707861 (+)
LP/J MGP_LPJ_G0034999
 protein coding gene Chr9:89396135-89443037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034903
 protein coding gene Chr9:96450912-96495809 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035619
 protein coding gene Chr9:88242569-88288009 (+)
PWK/PhJ MGP_PWKPhJ_G0033809
 protein coding gene Chr9:85758659-85809816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033645
 protein coding gene Chr9:88412177-88496853 (+)
WSB/EiJ MGP_WSBEiJ_G0034222
 protein coding gene Chr9:88270612-88318306 (+)



Homology
more
  • Human Ortholog
    NT5E, 5'-nucleotidase ecto
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NT5E, 5'-nucleotidase ecto
  • Synonyms
    CALJA, CD73, E5NT, eN, eNT, NT, NT5, NTE
  • Links
    NCBI Gene ID: 4907
    neXtProt AC: NX_P21589
    UniProt: P21589

  • Chr Location
    6q14.3; chr6:85449584-85495791 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NT5E associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    136 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele are viable and fertile with increased circulating alkaline phosphatase and impaired tubuloglomerular feedback regulation. Homozygous null mice for a second allele display increased vascular permeability especially under hypoxic conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1020
  • Tissues
    148
  • cDNA Data
    43
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23959 NCBI Gene Model | MGI Sequence Detail 44481 C57BL/6J ±  kb
    transcript NM_011851 RefSeq | MGI Sequence Detail 3580 ZRU/MplStud  
    polypeptide Q61503 UniProt | EBI | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 44
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16568, MGI:1921492, MGI:2143050
    References
    more
    • Summaries
      All 209
      Developmental Gene Expression 17
      Gene Ontology 15
      Phenotypes 136
    • Earliest
      J:14604 Berkemeier LR, et al., Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron. 1991 Nov;7(5):857-66
    • Latest
      J:355210 Serafin PK, et al., Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burden. Mol Metab. 2024 Nov;89:102035
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory