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Ppm1a Gene Detail
Summary
  • Symbol
    Ppm1a
  • Name
    protein phosphatase 1A, magnesium dependent, alpha isoform
  • Synonyms
    2310003C21Rik, 2900017D14Rik, MMPa-2, MPPa-1, Mpp alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99878
    NCBI Gene: 19042
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:72804231-72846593 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 30.26 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    898 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99878
 protein coding gene Chr12:72804229-72846593 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019829
 protein coding gene Chr12:72608283-72650400 (+)
A/J MGP_AJ_G0019787
 protein coding gene Chr12:69915375-69949576 (+)
AKR/J MGP_AKRJ_G0019762
 protein coding gene Chr12:72029614-72065959 (+)
BALB/cJ MGP_BALBcJ_G0019767
 protein coding gene Chr12:70390899-70424370 (+)
C3H/HeJ MGP_C3HHeJ_G0019572
 protein coding gene Chr12:72456667-72494578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020219
 protein coding gene Chr12:74887500-74924905 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0019124
 protein coding gene Chr12:67230894-67272846 (+)
CBA/J MGP_CBAJ_G0019542
 protein coding gene Chr12:77714968-77748626 (+)
DBA/2J MGP_DBA2J_G0019658
 protein coding gene Chr12:69801391-69835447 (+)
FVB/NJ MGP_FVBNJ_G0019645
 protein coding gene Chr12:68658963-68693763 (+)
LP/J MGP_LPJ_G0019730
 protein coding gene Chr12:72649823-72691749 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019684
 protein coding gene Chr12:80872199-80921549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020254
 protein coding gene Chr12:71497885-71538430 (+)
PWK/PhJ MGP_PWKPhJ_G0018889
 protein coding gene Chr12:64096674-64131605 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018684
 protein coding gene Chr12:65910653-65952698 (+)
WSB/EiJ MGP_WSBEiJ_G0019175
 protein coding gene Chr12:72100209-72137891 (+)



Homology
more
  • Human Ortholog
    PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A
  • Synonyms
    PP2CA, PP2Calpha, PP2C-ALPHA
  • Links
    NCBI Gene ID: 5494
    neXtProt AC: NX_P35813
    UniProt: P35813

  • Chr Location
    14q23.1; chr14:60245750-60299087 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed wound healing, delayed re-epithelialization, and decreased keratinocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    25
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19042 NCBI Gene Model | MGI Sequence Detail 42363 C57BL/6J ±  kb
    transcript NM_008910 RefSeq | MGI Sequence Detail 2789 C57BL/6  
    polypeptide P49443 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-16669, MGI:1916736, MGI:1920167, MGI:2144816, MGI:2144943
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:19652 Kato S, et al., The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. Gene. 1994 Aug 5;145(2):311-2
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory