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Slc1a3 Gene Detail
Summary
  • Symbol
    Slc1a3
  • Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 3
  • Synonyms
    B430115D02Rik, Eaat1, GLAST, Gmt1, MGluT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99917
    NCBI Gene: 20512
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:8663608-8740248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.82 cM, cytoband A2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2024 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99917
 protein coding gene Chr15:8663608-8742648 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021708
 protein coding gene Chr15:5730408-5814873 (-)
A/J MGP_AJ_G0021668
 protein coding gene Chr15:5567781-5648093 (-)
AKR/J MGP_AKRJ_G0021646
 protein coding gene Chr15:5624376-5703138 (-)
BALB/cJ MGP_BALBcJ_G0021675
 protein coding gene Chr15:5488383-5565189 (-)
C3H/HeJ MGP_C3HHeJ_G0021451
 protein coding gene Chr15:5666555-5750602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022114
 protein coding gene Chr15:5918762-5999434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019651
 protein coding gene Chr15:5149403-5226903 (-)
CAST/EiJ MGP_CASTEiJ_G0020967
 protein coding gene Chr15:5661072-5747927 (-)
CBA/J MGP_CBAJ_G0021420
 protein coding gene Chr15:6039147-6138069 (-)
DBA/2J MGP_DBA2J_G0021544
 protein coding gene Chr15:5475336-5553463 (-)
FVB/NJ MGP_FVBNJ_G0021522
 protein coding gene Chr15:5398418-5475484 (-)
LP/J MGP_LPJ_G0021612
 protein coding gene Chr15:5628552-5706614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021547
 protein coding gene Chr15:6296716-6384281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022137
 protein coding gene Chr15:5667946-5756017 (-)
PWK/PhJ MGP_PWKPhJ_G0020710
 protein coding gene Chr15:5497306-5576764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020548
 protein coding gene Chr15:5549368-5629672 (-)
WSB/EiJ MGP_WSBEiJ_G0021023
 protein coding gene Chr15:5609904-5691286 (-)



Homology
more
  • Human Ortholog
    SLC1A3, solute carrier family 1 member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC1A3, solute carrier family 1 member 3
  • Synonyms
    EA6, EAAT1, GLAST, GLAST1
  • Links
    NCBI Gene ID: 6507
    neXtProt AC: NX_P43003
    UniProt: P43003

  • Chr Location
    5p13.2; chr5:36596588-36688334 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc1a3 mouse models; 1 with human SLC1A3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display no abnormalities with respect to appearance or survival but do display functional abnormalities related to the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1310
  • Tissues
    272
  • cDNA Data
    26
  • Literature Summary
    183
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005360 Ensembl Gene Model | MGI Sequence Detail 76641 C57BL/6J ±  kb
    transcript ENSMUST00000005493 Ensembl | MGI Sequence Detail 4163 Not Applicable  
    polypeptide ENSMUSP00000005493 Ensembl | MGI Sequence Detail 543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014974 excitatory amino acid transporter 1
      (term hierarchy)
    • InterPro Domains
      IPR050746 Dicarboxylate/Amino Acid:Cation Symporter
      IPR001991 Sodium:dicarboxylate symporter
      IPR018107 Sodium:dicarboxylate symporter, conserved site
      IPR036458 Sodium:dicarboxylate symporter superfamily
    • GlyGen
      P56564 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 6
      cDNA 28
      Primer pair 5
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-16014, MGD-MRK-16274, MGD-MRK-16718, MGI:2146029, MGI:2444735
    References
    more
    • Summaries
      All 405
      Developmental Gene Expression 183
      Diseases 3
      Gene Ontology 26
      Phenotypes 160
    • Earliest
      J:16962 Tanaka K, Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993 Sep 3;159(1-2):183-6
    • Latest
      J:350432 Muhamad NA, et al., Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte. Cell Mol Neurobiol. 2024 Jun 1;44(1):48
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory