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Srms Gene Detail
Summary
  • Symbol
    Srms
  • Name
    src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
  • Synonyms
    A230069J08Rik, srm
  • Feature Type
    protein coding gene
  • IDs
    MGI:101865
    NCBI Gene: 20811
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180847356-180854964 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101865
 protein coding gene Chr2:180847355-180854978 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027014
 protein coding gene Chr2:187780859-187790061 (-)
A/J MGP_AJ_G0026980
 protein coding gene Chr2:180055469-180063106 (-)
AKR/J MGP_AKRJ_G0026950
 protein coding gene Chr2:185450229-185457953 (-)
BALB/cJ MGP_BALBcJ_G0026989
 protein coding gene Chr2:180521855-180529475 (-)
C3H/HeJ MGP_C3HHeJ_G0026730
 protein coding gene Chr2:185805961-185813618 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027435
 protein coding gene Chr2:193202744-193210362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024800
 protein coding gene Chr2:170740077-170750083 (-)
CAST/EiJ MGP_CASTEiJ_G0026189
 protein coding gene Chr2:184063878-184071480 (-)
CBA/J MGP_CBAJ_G0026707
 protein coding gene Chr2:200203217-200210819 (-)
DBA/2J MGP_DBA2J_G0026845
 protein coding gene Chr2:179149057-179156715 (-)
FVB/NJ MGP_FVBNJ_G0026811
 protein coding gene Chr2:177766109-177773738 (-)
LP/J MGP_LPJ_G0026946
 protein coding gene Chr2:187793785-187801527 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026830
 protein coding gene Chr2:202774343-202782008 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027494
 protein coding gene Chr2:185419901-185428521 (-)
PWK/PhJ MGP_PWKPhJ_G0025925
 protein coding gene Chr2:176674457-176682201 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025725
 protein coding gene Chr2:181907179-181914636 (-)
WSB/EiJ MGP_WSBEiJ_G0026261
 protein coding gene Chr2:186407968-186415623 (-)



Homology
more
  • Human Ortholog
    SRMS, src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRMS, src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
  • Synonyms
    C20orf148, dJ697K14.1, PTK70, SRM
  • Links
    NCBI Gene ID: 6725
    neXtProt AC: NX_Q9H3Y6
    UniProt: Q9H3Y6

  • Chr Location
    chr20:63538489-63547749 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Homozygous mice exhibit no detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    45
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20811 NCBI Gene Model | MGI Sequence Detail 7609 C57BL/6J ±  kb
transcript NM_011481 RefSeq | MGI Sequence Detail 2505 C57BL/6  
polypeptide Q62270 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18690, MGI:2444916
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:20410 Kohmura N, et al., A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. Mol Cell Biol. 1994 Oct;14(10):6915-25
  • Latest
    J:307124 Park JM, et al., The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51. PLoS Biol. 2021 Jun;19(6):e3001281
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory