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Mef2b Gene Detail
Summary
  • Symbol
    Mef2b
  • Name
    myocyte enhancer factor 2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:104526
    NCBI Gene: 17259
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70605411-70620138 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104526
 protein coding gene Chr8:70592361-70620138 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033693
 protein coding gene Chr8:70402967-70420687 (+)
A/J MGP_AJ_G0033676
 protein coding gene Chr8:67539709-67555071 (+)
AKR/J MGP_AKRJ_G0033601
 protein coding gene Chr8:69460052-69475978 (+)
BALB/cJ MGP_BALBcJ_G0033672
 protein coding gene Chr8:67769333-67783854 (+)
C3H/HeJ MGP_C3HHeJ_G0033382
 protein coding gene Chr8:70105627-70125108 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034189
 protein coding gene Chr8:73069103-73088223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031133
 protein coding gene Chr8:62358402-62375060 (+)
CAST/EiJ MGP_CASTEiJ_G0032707
 protein coding gene Chr8:69591780-69604869 (+)
CBA/J MGP_CBAJ_G0033360
 protein coding gene Chr8:75708807-75724968 (+)
DBA/2J MGP_DBA2J_G0033514
 protein coding gene Chr8:67266757-67282886 (+)
FVB/NJ MGP_FVBNJ_G0033455
 protein coding gene Chr8:66369086-66384638 (+)
LP/J MGP_LPJ_G0033601
 protein coding gene Chr8:70441275-70455381 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0034207
 protein coding gene Chr8:69642522-69659827 (+)
PWK/PhJ MGP_PWKPhJ_G0032415
 protein coding gene Chr8:66551934-66569021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032251
 protein coding gene Chr8:68615056-68631056 (+)
WSB/EiJ MGP_WSBEiJ_G0032822
 protein coding gene Chr8:70004761-70021602 (+)



Homology
more
  • Human Ortholog
    BORCS8-MEF2B, BORCS8-MEF2B readthrough
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BORCS8-MEF2B, BORCS8-MEF2B readthrough
  • Synonyms
    LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, RSRFR2
  • Links
    NCBI Gene ID: 4207
    neXtProt AC: NX_Q02080
    UniProt: Q02080

  • Chr Location
    19p13.11; chr19:19145567-19192158 (-)  GRCh38
  • Human Ortholog
    MEF2B, myocyte enhancer factor 2B
  • Synonyms
    RSRFR2
  • Links
    NCBI Gene ID: 100271849
    neXtProt AC: NX_Q02080
    UniProt: Q02080

  • Chr Location
    19p13.11; chr19:19145567-19192131 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    92
  • cDNA Data
    14
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17259 NCBI Gene Model | MGI Sequence Detail 14728 C57BL/6J ±  kb
    transcript NM_001045484 RefSeq | MGI Sequence Detail 1339 ZRU/MplStud  
    polypeptide O55087 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 14
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-25957, MGI:2142554, MGI:3779429
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 18
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:28136 Lyons GE, et al., Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci. 1995 Aug;15(8):5727-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory