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Efnb2 Gene Detail
Summary
  • Symbol
    Efnb2
  • Name
    ephrin B2
  • Synonyms
    ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105097
    NCBI Gene: 13642
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:8667434-8711242 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 3.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    996 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105097
 protein coding gene Chr8:8667235-8711242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033341
 protein coding gene Chr8:5690612-5733731 (-)
A/J MGP_AJ_G0033321
 protein coding gene Chr8:5505824-5549059 (-)
AKR/J MGP_AKRJ_G0033253
 protein coding gene Chr8:5686204-5729736 (-)
BALB/cJ MGP_BALBcJ_G0033322
 protein coding gene Chr8:5639724-5684692 (-)
C3H/HeJ MGP_C3HHeJ_G0033036
 protein coding gene Chr8:5840381-5884824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033834
 protein coding gene Chr8:5962494-6006662 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030805
 protein coding gene Chr8:5097626-5141090 (-)
CAST/EiJ MGP_CASTEiJ_G0032358
 protein coding gene Chr8:5505220-5550842 (-)
CBA/J MGP_CBAJ_G0033009
 protein coding gene Chr8:6210411-6265324 (-)
DBA/2J MGP_DBA2J_G0033162
 protein coding gene Chr8:5515629-5559275 (-)
FVB/NJ MGP_FVBNJ_G0033110
 protein coding gene Chr8:5457460-5501796 (-)
LP/J MGP_LPJ_G0033256
 protein coding gene Chr8:5598317-5641461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033145
 protein coding gene Chr8:6646169-6689393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033851
 protein coding gene Chr8:5678932-5722102 (-)
PWK/PhJ MGP_PWKPhJ_G0032071
 protein coding gene Chr8:5447081-5490699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031913
 protein coding gene Chr8:5570510-5613766 (-)
WSB/EiJ MGP_WSBEiJ_G0032474
 protein coding gene Chr8:5734058-5780018 (-)



Homology
more
  • Human Ortholog
    EFNB2, ephrin B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNB2, ephrin B2
  • Synonyms
    ephrin-B2, EPLG5, Htk-L, HTKL, LERK5
  • Links
    NCBI Gene ID: 1948
    neXtProt AC: NX_P52799
    UniProt: P52799

  • Chr Location
    13q33.3; chr13:106489745-106535662 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human EFNB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 13 alleles in 14 genetic backgrounds
    36 phenotypes from multigenic genotypes
    1 images
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defects in angiogenesis of both arteries and veins and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1329
  • Tissues
    315
  • cDNA Data
    89
  • Literature Summary
    237
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001300 Ensembl Gene Model | MGI Sequence Detail 43809 C57BL/6J ±  kb
    transcript ENSMUST00000001319 Ensembl | MGI Sequence Detail 4793 Not Applicable  
    polypeptide ENSMUSP00000001319 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 92
      Primer pair 13
      Other 16

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-32137
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 237
      Gene Ontology 22
      Phenotypes 138
    • Earliest
      J:45123 Bonaldo MF, et al., Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13. Hum Mol Genet. 1994 Sep;3(9):1663-73
    • Latest
      J:355222 Nord C, et al., Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn. 2024 Oct;253(10):922-939
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory