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Spink1 Gene Detail
Summary
  • Symbol
    Spink1
  • Name
    serine peptidase inhibitor, Kazal type 1
  • Synonyms
    p12, prostatic secretory glycoprotein, Spink3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106202
    NCBI Gene: 20730
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:43861134-43870302 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.47 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106202
 protein coding gene Chr18:43861134-43870622 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024387
 protein coding gene Chr18:42448374-42459101 (-)
A/J MGP_AJ_G0024354
 protein coding gene Chr18:40948130-40962233 (-)
AKR/J MGP_AKRJ_G0024323
 protein coding gene Chr18:42077756-42090182 (-)
BALB/cJ MGP_BALBcJ_G0024354
 protein coding gene Chr18:41033514-41046219 (-)
C3H/HeJ MGP_C3HHeJ_G0024121
 protein coding gene Chr18:42133070-42144077 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024798
 protein coding gene Chr18:43931966-43941134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022234
 protein coding gene Chr18:40767760-40777143 (-)
CAST/EiJ MGP_CASTEiJ_G0023595
 protein coding gene Chr18:42124018-42133233 (-)
CBA/J MGP_CBAJ_G0024090
 protein coding gene Chr18:45163261-45174376 (-)
DBA/2J MGP_DBA2J_G0024220
 protein coding gene Chr18:40542159-40551853 (-)
FVB/NJ MGP_FVBNJ_G0024186
 protein coding gene Chr18:40147159-40156849 (-)
LP/J MGP_LPJ_G0024304
 protein coding gene Chr18:42474423-42485736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024217
 protein coding gene Chr18:46462241-46471409 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024845
 protein coding gene Chr18:41962423-41971591 (-)
PWK/PhJ MGP_PWKPhJ_G0023339
 protein coding gene Chr18:40763050-40772619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023144
 protein coding gene Chr18:42216543-42225248 (-)
WSB/EiJ MGP_WSBEiJ_G0023658
 protein coding gene Chr18:41877064-41886260 (-)



Homology
more
  • Human Ortholog
    SPINK1, serine peptidase inhibitor Kazal type 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPINK1, serine peptidase inhibitor Kazal type 1
  • Synonyms
    PCTT, PSTI, Spink3, TATI, TCP
  • Links
    NCBI Gene ID: 6690
    neXtProt AC: NX_P00995
    UniProt: P00995

  • Chr Location
    5q32; chr5:147824572-147839196 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPINK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene results in postnatal lethality, growth retardation, dehydration, autophagic degeneration of acinar cells resulting in pancreas trophy, small intestine degeneration, and a small spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    65
  • cDNA Data
    60
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20730 NCBI Gene Model | MGI Sequence Detail 9169 C57BL/6J ±  kb
    transcript NM_009258 RefSeq | MGI Sequence Detail 422 C57BL/6  
    polypeptide P09036 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 2
      cDNA 60
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33893
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 15
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:52103 Small JA, et al., Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8288-92
    • Latest
      J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory