Matn1 MGI Mouse Gene Detail - MGI:106591 - matrilin 1, cartilage matrix protein

Symbol

Matn1
Name

matrilin 1, cartilage matrix protein
Synonyms

CMP, Crtm, Mat1, matrilin-1

Feature Type

protein coding gene
IDs

MGI:106591
NCBI Gene: 17180
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:130671696-130682786 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 64.09 cM
Mapping Data

3 experiments

SNPs within 2kb

91 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106591	protein coding gene	Chr4:130671696-130682787 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028856	protein coding gene	Chr4:132998107-133008229 (+)
A/J	MGP_AJ_G0028815	protein coding gene	Chr4:127480188-127490613 (+)
AKR/J	MGP_AKRJ_G0028768	protein coding gene	Chr4:131062882-131074355 (+)
BALB/cJ	MGP_BALBcJ_G0028838	protein coding gene	Chr4:128096022-128106060 (+)
C3H/HeJ	MGP_C3HHeJ_G0028552	protein coding gene	Chr4:131290347-131300882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029280	protein coding gene	Chr4:137800142-137809501 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026552	protein coding gene	Chr4:120580182-120589432 (+)
CAST/EiJ	MGP_CASTEiJ_G0027985	protein coding gene	Chr4:129341720-129356220 (+)
CBA/J	MGP_CBAJ_G0028518	protein coding gene	Chr4:141319242-141334284 (+)
DBA/2J	MGP_DBA2J_G0028667	protein coding gene	Chr4:127913114-127922507 (+)
FVB/NJ	MGP_FVBNJ_G0028634	protein coding gene	Chr4:126738847-126748257 (+)
LP/J	MGP_LPJ_G0028768	protein coding gene	Chr4:133154220-133165803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028660	protein coding gene	Chr4:146000410-146009828 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029318	protein coding gene	Chr4:131437963-131447410 (+)
PWK/PhJ	MGP_PWKPhJ_G0027706	protein coding gene	Chr4:124553603-124564303 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027532	protein coding gene	Chr4:127298220-127307498 (+)
WSB/EiJ	MGP_WSBEiJ_G0028065	protein coding gene	Chr4:131594516-131604853 (+)

Human Ortholog

MATN1, matrilin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MATN1, matrilin 1
Synonyms

CMP, CRTM
Links

HGNC:6907

NCBI Gene ID: 4146

neXtProt AC: NX_P21941

UniProt: P21941
Chr Location

1p35.2; chr1:30711277-30723585 (-) GRCh38

MGI Vertebrate Homology

Matn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MATN1
Gene Tree

Matn1

less

Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Matn1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are viable, fertile and display normal cartilage development and endochondral bone formation. Mice homozygous for one targeted allele show alterations in type II collagen fibrillogenesis and fibril organization, in the absence of skeletal defects.

less

All GO Annotations

14
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1078
Tissues

98
cDNA Data

23
Literature Summary

37

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MATN1

Xenbase matn1

ZFIN matn1

less

All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS18713.1

Ensembl

ENSMUSG00000040533 (Evidence)
NCBI Gene

17180

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040533	Ensembl Gene Model \| MGI Sequence Detail	11091	C57BL/6J	± kb
transcript	ENSMUST00000102576	Ensembl \| MGI Sequence Detail	2001	Not Applicable
polypeptide	ENSMUSP00000099636	Ensembl \| MGI Sequence Detail	500	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000010205 cartilage matrix protein

(term hierarchy)
InterPro Domains

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR050525 Extracellular Matrix Assembly and Organization

IPR036337 Matrilin, coiled-coil domain superfamily

IPR019466 Matrilin, coiled-coil trimerisation domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

P51942 2 sites, 1 N-linked glycan (1 site)

less

All nucleic 33

Genomic 1

cDNA 23

Primer pair 8

Other 1

Microarray probesets 3

less

MGD-MRK-35047

Summaries

All 83

Developmental Gene Expression 37

Gene Ontology 10

Phenotypes 17
Earliest

J:320146 Winterbottom N, et al., Cartilage matrix protein is a component of the collagen fibril of cartilage. Dev Dyn. 1992 Mar;193(3):266-76
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Matn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39350	Chr4:130671688-130671702 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24