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Stxbp3 Gene Detail
Summary
  • Symbol
    Stxbp3
  • Name
    syntaxin binding protein 3
  • Synonyms
    Munc-18c, Stxbp3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:107362
    NCBI Gene: 20912
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108700496-108747818 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.73 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107362
 protein coding gene Chr3:108700492-108747842 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027786
 protein coding gene Chr3:110374400-110421656 (-)
A/J MGP_AJ_G0027746
 protein coding gene Chr3:106867049-106916832 (-)
AKR/J MGP_AKRJ_G0027711
 protein coding gene Chr3:109467742-109518037 (-)
BALB/cJ MGP_BALBcJ_G0027758
 protein coding gene Chr3:106567469-106617528 (-)
C3H/HeJ MGP_C3HHeJ_G0027488
 protein coding gene Chr3:109824371-109873933 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028202
 protein coding gene Chr3:114463941-114517565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025540
 protein coding gene Chr3:102994069-103042510 (-)
CAST/EiJ MGP_CASTEiJ_G0026944
 protein coding gene Chr3:109217568-109265219 (-)
CBA/J MGP_CBAJ_G0027463
 protein coding gene Chr3:118380271-118436814 (-)
DBA/2J MGP_DBA2J_G0027605
 protein coding gene Chr3:106039121-106086071 (-)
FVB/NJ MGP_FVBNJ_G0027573
 protein coding gene Chr3:103925040-103971636 (-)
LP/J MGP_LPJ_G0027712
 protein coding gene Chr3:111791932-111846660 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027603
 protein coding gene Chr3:124423818-124486756 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028257
 protein coding gene Chr3:109066082-109119977 (-)
PWK/PhJ MGP_PWKPhJ_G0026670
 protein coding gene Chr3:105794385-105841827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026490
 protein coding gene Chr3:107212316-107264442 (-)
WSB/EiJ MGP_WSBEiJ_G0027024
 protein coding gene Chr3:109603370-109654119 (-)



Homology
more
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STXBP3, syntaxin binding protein 3
  • Synonyms
    MUNC18-3, MUNC18C, PSP, UNC-18C
  • Links
    NCBI Gene ID: 6814
    neXtProt AC: NX_O00186
    UniProt: O00186

  • Chr Location
    1p13.3; chr1:108746674-108809523 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic or perinatal lethality with reduced embryonic growth and malformation of the intermediate zone of the cerebral cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20912 NCBI Gene Model | MGI Sequence Detail 47323 C57BL/6J ±  kb
    transcript NM_011504 RefSeq | MGI Sequence Detail 2406 BALB/c  
    polypeptide Q60770 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33865, MGD-MRK-35828
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 16
      Phenotypes 14
    • Earliest
      J:28512 Tellam JT, et al., Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem. 1995 Mar 17;270(11):5857-63
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory