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Lxn Gene Detail
Summary
  • Symbol
    Lxn
  • Name
    latexin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107633
    NCBI Gene: 17035
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:67365332-67371240 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.98 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107633
 protein coding gene Chr3:67365331-67371259 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027281
 protein coding gene Chr3:66614600-66620528 (-)
A/J MGP_AJ_G0027243
 protein coding gene Chr3:64650269-64656197 (-)
AKR/J MGP_AKRJ_G0027211
 protein coding gene Chr3:66047016-66052932 (-)
BALB/cJ MGP_BALBcJ_G0027254
 protein coding gene Chr3:64525786-64531702 (-)
C3H/HeJ MGP_C3HHeJ_G0026998
 protein coding gene Chr3:66287181-66293109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027700
 protein coding gene Chr3:69104041-69109969 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025053
 protein coding gene Chr3:60980912-60986791 (-)
CAST/EiJ MGP_CASTEiJ_G0026445
 protein coding gene Chr3:66233852-66239773 (-)
CBA/J MGP_CBAJ_G0026973
 protein coding gene Chr3:71262880-71268796 (-)
DBA/2J MGP_DBA2J_G0027109
 protein coding gene Chr3:64164020-64169936 (-)
FVB/NJ MGP_FVBNJ_G0027077
 protein coding gene Chr3:62796620-62802536 (-)
LP/J MGP_LPJ_G0027217
 protein coding gene Chr3:67537155-67543083 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027096
 protein coding gene Chr3:75919859-75925775 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027758
 protein coding gene Chr3:65923195-65929111 (-)
PWK/PhJ MGP_PWKPhJ_G0026179
 protein coding gene Chr3:63901655-63907666 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025995
 protein coding gene Chr3:65027153-65033076 (-)
WSB/EiJ MGP_WSBEiJ_G0026523
 protein coding gene Chr3:66037595-66043525 (-)



Homology
more
  • Human Ortholog
    LXN, latexin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LXN, latexin
  • Synonyms
    ECI, TCI
  • Links
    NCBI Gene ID: 56925
    neXtProt AC: NX_Q9BS40
    UniProt: Q9BS40

  • Chr Location
    3q25.32; chr3:158645822-158672648 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    22
  • cDNA Data
    82
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17035 NCBI Gene Model | MGI Sequence Detail 5909 C57BL/6J ±  kb
transcript NM_016753 RefSeq | MGI Sequence Detail 1092 ZRU/MplStud  
polypeptide P70202 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 1
    cDNA 83

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36207
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:37801 Jin M, et al., Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner. Genomics. 1997 Feb 1;39(3):419-21
  • Latest
    J:345751 Cui X, et al., Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1. Cell Rep. 2023 Mar 28;42(3):112274
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory