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Wnt8a Gene Detail
Summary
  • Symbol
    Wnt8a
  • Name
    wingless-type MMTV integration site family, member 8A
  • Synonyms
    Stra11
  • Feature Type
    protein coding gene
  • IDs
    MGI:107924
    NCBI Gene: 20890
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34675380-34681114 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.69 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107924
 protein coding gene Chr18:34675366-34681326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024241
 protein coding gene Chr18:32750398-32756351 (+)
A/J MGP_AJ_G0024207
 protein coding gene Chr18:31655206-31661159 (+)
AKR/J MGP_AKRJ_G0024176
 protein coding gene Chr18:32552655-32558615 (+)
BALB/cJ MGP_BALBcJ_G0024207
 protein coding gene Chr18:31712969-31718922 (+)
C3H/HeJ MGP_C3HHeJ_G0023975
 protein coding gene Chr18:32568554-32574506 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024649
 protein coding gene Chr18:34003973-34009933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022090
 protein coding gene Chr18:31798594-31804516 (+)
CAST/EiJ MGP_CASTEiJ_G0023450
 protein coding gene Chr18:32520847-32526815 (+)
CBA/J MGP_CBAJ_G0023943
 protein coding gene Chr18:34946345-34952298 (+)
DBA/2J MGP_DBA2J_G0024075
 protein coding gene Chr18:31311369-31317322 (+)
FVB/NJ MGP_FVBNJ_G0024041
 protein coding gene Chr18:30998791-31004751 (+)
LP/J MGP_LPJ_G0024156
 protein coding gene Chr18:32841278-32847229 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024069
 protein coding gene Chr18:36218165-36224117 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024697
 protein coding gene Chr18:32377432-32383392 (+)
PWK/PhJ MGP_PWKPhJ_G0023193
 protein coding gene Chr18:31500699-31506694 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023002
 protein coding gene Chr18:32646429-32652400 (+)
WSB/EiJ MGP_WSBEiJ_G0023513
 protein coding gene Chr18:32292230-32298183 (+)



Homology
more
  • Human Ortholog
    WNT8A, Wnt family member 8A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT8A, Wnt family member 8A
  • Synonyms
    WNT8D
  • Links
    NCBI Gene ID: 7478
    neXtProt AC: NX_Q9H1J5
    UniProt: Q9H1J5

  • Chr Location
    5q31.2; chr5:138077367-138092365 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1350
  • Tissues
    494
  • cDNA Data
    14
  • Literature Summary
    70
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20890 NCBI Gene Model | MGI Sequence Detail 5735 C57BL/6J ±  kb
transcript NM_009290 RefSeq | MGI Sequence Detail 1520 C57BL/6  
polypeptide Q64527 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 16
    Primer pair 14
    Other 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36504
References
more
  • Summaries
    All 96
    Developmental Gene Expression 70
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
  • Latest
    J:331973 Simonson L, et al., Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development. Development. 2022 Nov 15;149(22):dev200816
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory