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Igfals Gene Detail
Summary
  • Symbol
    Igfals
  • Name
    insulin-like growth factor binding protein, acid labile subunit
  • Synonyms
    Albs, ALS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107973
    NCBI Gene: 16005
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:25096818-25100985 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A2-A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107973
 protein coding gene Chr17:25084971-25100985 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023326
 protein coding gene Chr17:23904217-23907455 (+)
A/J MGP_AJ_G0023286
 protein coding gene Chr17:23240950-23244189 (+)
AKR/J MGP_AKRJ_G0023253
 protein coding gene Chr17:23329505-23332743 (+)
BALB/cJ MGP_BALBcJ_G0023291
 protein coding gene Chr17:23441471-23444709 (+)
C3H/HeJ MGP_C3HHeJ_G0023051
 protein coding gene Chr17:23694103-23697341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023734
 protein coding gene Chr17:24967080-24970318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021209
 protein coding gene Chr17:20701329-20704503 (+)
CAST/EiJ MGP_CASTEiJ_G0022553
 protein coding gene Chr17:23549334-23552573 (+)
CBA/J MGP_CBAJ_G0023027
 protein coding gene Chr17:25808393-25811631 (+)
DBA/2J MGP_DBA2J_G0023156
 protein coding gene Chr17:22833613-22836852 (+)
FVB/NJ MGP_FVBNJ_G0023126
 protein coding gene Chr17:22554167-22557405 (+)
LP/J MGP_LPJ_G0023233
 protein coding gene Chr17:24209480-24212718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023145
 protein coding gene Chr17:25500815-25504054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023772
 protein coding gene Chr17:23613954-23617193 (+)
PWK/PhJ MGP_PWKPhJ_G0022302
 protein coding gene Chr17:21589030-21592268 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022120
 protein coding gene Chr17:21678262-21681500 (+)
WSB/EiJ MGP_WSBEiJ_G0022616
 protein coding gene Chr17:23686600-23689839 (+)



Homology
more
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
  • Synonyms
    ACLSD, ALS
  • Links
    NCBI Gene ID: 3483
    neXtProt AC: NX_P35858
    UniProt: P35858

  • Chr Location
    16p13.3; chr16:1790413-1794971 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene gain weight more slowly after birth and display less growth in long bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    46
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16005 NCBI Gene Model | MGI Sequence Detail 4168 C57BL/6J ±  kb
    transcript NM_001364896 RefSeq | MGI Sequence Detail 2232 ZRU/MplStud  
    polypeptide P70389 UniProt | EBI | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008946 insulin-like growth factor-binding protein complex acid labile chain
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
      IPR050333 Small Leucine-Rich Proteoglycans
    • GlyGen
      P70389 7 sites
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 3
      cDNA 46
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36553
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:35394 Boisclair YR, et al., Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10028-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory