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Wnt10a Gene Detail
Summary
  • Symbol
    Wnt10a
  • Name
    wingless-type MMTV integration site family, member 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:108071
    NCBI Gene: 22409
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74831178-74843335 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108071
 protein coding gene Chr1:74830675-74843338 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016163
 protein coding gene Chr1:75402286-75414933 (+)
A/J MGP_AJ_G0016146
 protein coding gene Chr1:72777605-72789040 (+)
AKR/J MGP_AKRJ_G0016103
 protein coding gene Chr1:74783486-74795147 (+)
BALB/cJ MGP_BALBcJ_G0016101
 protein coding gene Chr1:72833072-72844447 (+)
C3H/HeJ MGP_C3HHeJ_G0015932
 protein coding gene Chr1:75128407-75142191 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016554
 protein coding gene Chr1:78342133-78354075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014275
 protein coding gene Chr1:68341673-68354075 (+)
CAST/EiJ MGP_CASTEiJ_G0015516
 protein coding gene Chr1:74451177-74463806 (+)
CBA/J MGP_CBAJ_G0015905
 protein coding gene Chr1:80889809-80901174 (+)
DBA/2J MGP_DBA2J_G0016006
 protein coding gene Chr1:72094602-72106117 (+)
FVB/NJ MGP_FVBNJ_G0016009
 protein coding gene Chr1:71288099-71300028 (+)
LP/J MGP_LPJ_G0016078
 protein coding gene Chr1:76519473-76532026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016029
 protein coding gene Chr1:84272634-84287110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016601
 protein coding gene Chr1:74859759-74872421 (+)
PWK/PhJ MGP_PWKPhJ_G0015303
 protein coding gene Chr1:71554509-71567519 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015081
 protein coding gene Chr1:74227413-74239379 (+)
WSB/EiJ MGP_WSBEiJ_G0015578
 protein coding gene Chr1:74673315-74686488 (+)



Homology
more
  • Human Ortholog
    WNT10A, Wnt family member 10A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT10A, Wnt family member 10A
  • Synonyms
    ECTD16, OODD, SSPS, STHAG4
  • Links
    NCBI Gene ID: 80326
    neXtProt AC: NX_Q9GZT5
    UniProt: Q9GZT5

  • Chr Location
    2q35; chr2:218874116-218899581 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human WNT10A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit taurodontism, supernumerary molars, small molars and misshapened crowns. Mice homozygous for a conditional allele activated in Krt14+ cells also exhibit decreased basal cell proliferation affecting the tongue, sweat glands and nails.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1525
  • Tissues
    545
  • cDNA Data
    15
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22409 NCBI Gene Model | MGI Sequence Detail 12158 C57BL/6J ±  kb
    transcript NM_009518 RefSeq | MGI Sequence Detail 1977 Not Specified  
    polypeptide P70701 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 20
      Primer pair 11
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37108
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 81
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353358 Sun K, et al., A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning. Int J Oral Sci. 2024 Mar 13;16(1):25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory