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Adcyap1r1 Gene Detail
Summary
  • Symbol
    Adcyap1r1
  • Name
    adenylate cyclase activating polypeptide 1 receptor 1
  • Synonyms
    2900024I10Rik, PAC1, PAC1R, PACAP1-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:108449
    NCBI Gene: 11517
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55428963-55478436 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.38 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1537 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108449
 protein coding gene Chr6:55428486-55478440 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030774
 protein coding gene Chr6:54862247-54913493 (+)
A/J MGP_AJ_G0030743
 protein coding gene Chr6:52312567-52361944 (+)
AKR/J MGP_AKRJ_G0030670
 protein coding gene Chr6:54087344-54138140 (+)
BALB/cJ MGP_BALBcJ_G0030755
 protein coding gene Chr6:52683891-52733241 (+)
C3H/HeJ MGP_C3HHeJ_G0030468
 protein coding gene Chr6:54118734-54169320 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031210
 protein coding gene Chr6:56085380-56134791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028416
 protein coding gene Chr6:49920424-49970279 (+)
CAST/EiJ MGP_CASTEiJ_G0029871
 protein coding gene Chr6:53975254-54030610 (+)
CBA/J MGP_CBAJ_G0030442
 protein coding gene Chr6:58379208-58428528 (+)
DBA/2J MGP_DBA2J_G0030592
 protein coding gene Chr6:52211554-52260859 (+)
FVB/NJ MGP_FVBNJ_G0030544
 protein coding gene Chr6:51812326-51861646 (+)
LP/J MGP_LPJ_G0030677
 protein coding gene Chr6:54791842-54841149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030578
 protein coding gene Chr6:60886321-60935624 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031240
 protein coding gene Chr6:54063247-54112603 (+)
PWK/PhJ MGP_PWKPhJ_G0029584
 protein coding gene Chr6:51878971-51928782 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029418
 protein coding gene Chr6:53442982-53493134 (+)
WSB/EiJ MGP_WSBEiJ_G0029948
 protein coding gene Chr6:54092654-54145385 (+)



Homology
more
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCYAP1R1, ADCYAP receptor type I
  • Synonyms
    PAC1, PAC1R, PACAPR, PACAPRI
  • Links
    NCBI Gene ID: 117
    neXtProt AC: NX_P41586
    UniProt: P41586

  • Chr Location
    7p14.3; chr7:31052308-31111474 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations affect contextual fear conditioning, elevated locomotor activity, anxiety-like behavior, susceptibility to endotoxic shock, circadian responses to a photic stimulus, and glucose tolerance. Some alleles affect female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1147
  • Tissues
    113
  • cDNA Data
    78
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029778 Ensembl Gene Model | MGI Sequence Detail 49474 C57BL/6J ±  kb
    transcript ENSMUST00000167234 Ensembl | MGI Sequence Detail 1575 Not Applicable  
    polypeptide ENSMUSP00000126994 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000003762 pituitary adenylate cyclase-activating polypeptide type I receptor
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      P70205 3 sites
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 7
      cDNA 82
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37493, MGI:1920204, MGI:2141492
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 43
    • Earliest
      J:35894 Spengler D, et al., Differential signal transduction by five splice variants of the PACAP receptor. Nature. 1993 Sep 9;365(6442):170-5
    • Latest
      J:350522 Son H, et al., PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice. J Headache Pain. 2024 May 28;25(1):87
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory