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Tbc1d14 Gene Detail
Summary
  • Symbol
    Tbc1d14
  • Name
    TBC1 domain family, member 14
  • Synonyms
    2810413P16Rik, D5Ertd110e, mKIAA1322
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098708
    NCBI Gene: 100855
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36647948-36743611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098708
 protein coding gene Chr5:36647948-36750620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029491
 protein coding gene Chr5:34826683-34936998 (-)
A/J MGP_AJ_G0029458
 protein coding gene Chr5:33685038-33785381 (-)
AKR/J MGP_AKRJ_G0029407
 protein coding gene Chr5:34952524-35069496 (-)
BALB/cJ MGP_BALBcJ_G0029468
 protein coding gene Chr5:34193660-34298661 (-)
C3H/HeJ MGP_C3HHeJ_G0029190
 protein coding gene Chr5:34974610-35079705 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029922
 protein coding gene Chr5:36736806-36845942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027159
 protein coding gene Chr5:31428939-31531944 (-)
CAST/EiJ MGP_CASTEiJ_G0028599
 protein coding gene Chr5:34097603-34212004 (-)
CBA/J MGP_CBAJ_G0029158
 protein coding gene Chr5:37616067-37734239 (-)
DBA/2J MGP_DBA2J_G0029306
 protein coding gene Chr5:33822584-33926891 (-)
FVB/NJ MGP_FVBNJ_G0029265
 protein coding gene Chr5:33302039-33405287 (-)
LP/J MGP_LPJ_G0029391
 protein coding gene Chr5:35277608-35395375 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029295
 protein coding gene Chr5:38371842-38487332 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029955
 protein coding gene Chr5:34455439-34564086 (-)
PWK/PhJ MGP_PWKPhJ_G0028324
 protein coding gene Chr5:32999548-33103270 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028155
 protein coding gene Chr5:33927391-34034551 (-)
WSB/EiJ MGP_WSBEiJ_G0028680
 protein coding gene Chr5:34540485-34647262 (-)



Homology
more
  • Human Ortholog
    TBC1D14, TBC1 domain family member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D14, TBC1 domain family member 14
  • Links
    NCBI Gene ID: 57533
    neXtProt AC: NX_Q9P2M4
    UniProt: Q9P2M4

  • Chr Location
    4p16.1; chr4:6909242-7033118 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    18
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    8 involving Tbc1d14
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    36 strains or lines available
Embryos homozygous for an ENU-induced mutation appear arrested at an egg cylinder-like state and show complete embryonic lethality between implantation and placentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    19
  • cDNA Data
    179
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100855 NCBI Gene Model | MGI Sequence Detail 95664 C57BL/6J ±  kb
transcript NM_001113362 RefSeq | MGI Sequence Detail 4783 ZRU/MplStud  
polypeptide Q8CGA2 UniProt | EBI | MGI Sequence Detail 694 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 181
    cDNA 180
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919674, MGI:2141090, MGI:2141331
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 29
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory