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Cd200 Gene Detail
Summary
  • Symbol
    Cd200
  • Name
    CD200 molecule
  • Synonyms
    Mox2, MRC OX-2, OX2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196990
    NCBI Gene: 17470
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:45202498-45229416 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 29.53 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    755 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196990
 protein coding gene Chr16:45202474-45229419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022851
 protein coding gene Chr16:44175875-44203440 (-)
A/J MGP_AJ_G0022816
 protein coding gene Chr16:42201251-42228072 (-)
AKR/J MGP_AKRJ_G0022788
 protein coding gene Chr16:43582757-43610520 (-)
BALB/cJ MGP_BALBcJ_G0022817
 protein coding gene Chr16:42212062-42239474 (-)
C3H/HeJ MGP_C3HHeJ_G0022581
 protein coding gene Chr16:43745303-43777608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023264
 protein coding gene Chr16:45169444-45196781 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020778
 protein coding gene Chr16:42581886-42609608 (-)
CAST/EiJ MGP_CASTEiJ_G0022106
 protein coding gene Chr16:43925865-43954814 (-)
CBA/J MGP_CBAJ_G0022552
 protein coding gene Chr16:47086267-47115085 (-)
DBA/2J MGP_DBA2J_G0022684
 protein coding gene Chr16:41938802-41965231 (-)
FVB/NJ MGP_FVBNJ_G0022660
 protein coding gene Chr16:41850896-41878556 (-)
LP/J MGP_LPJ_G0022752
 protein coding gene Chr16:43905064-43933878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022678
 protein coding gene Chr16:46493683-46522918 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023279
 protein coding gene Chr16:43597070-43627556 (-)
PWK/PhJ MGP_PWKPhJ_G0021846
 protein coding gene Chr16:42306492-42333560 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021677
 protein coding gene Chr16:43526236-43555561 (-)
WSB/EiJ MGP_WSBEiJ_G0022151
 protein coding gene Chr16:43688549-43716320 (-)



Homology
more
  • Human Ortholog
    CD200, CD200 molecule
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD200, CD200 molecule
  • Synonyms
    MOX1, MOX2, MRC, OX-2
  • Links
    NCBI Gene ID: 4345
    neXtProt AC: NX_P41217
    UniProt: P41217

  • Chr Location
    3q13.2; chr3:112332235-112363181 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cd200 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have increased levels of all macrophage lineages. Macrophage are activated and mice display an increased susceptibility to autoimmune disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    991
  • Tissues
    86
  • cDNA Data
    14
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022661 Ensembl Gene Model | MGI Sequence Detail 26919 C57BL/6J ±  kb
    transcript ENSMUST00000163230 Ensembl | MGI Sequence Detail 2347 Not Applicable  
    polypeptide ENSMUSP00000130518 Ensembl | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 8
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 10
      Phenotypes 30
    • Earliest
      J:44890 Chen Z, et al., Cloning and characterization of the murine homologue of the rat/human MRC OX-2 gene. Biochim Biophys Acta. 1997 Nov 28;1362(1):6-10
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory