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Copa Gene Detail
Summary
  • Symbol
    Copa
  • Name
    coatomer protein complex subunit alpha
  • Synonyms
    xenin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334462
    NCBI Gene: 12847
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171910096-171949897 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    997 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334462
 protein coding gene Chr1:171909885-171949899 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016777
 protein coding gene Chr1:177931821-177971600 (+)
A/J MGP_AJ_G0016756
 protein coding gene Chr1:170649611-170688900 (+)
AKR/J MGP_AKRJ_G0016722
 protein coding gene Chr1:175807621-175849011 (+)
BALB/cJ MGP_BALBcJ_G0016717
 protein coding gene Chr1:171197208-171236411 (+)
C3H/HeJ MGP_C3HHeJ_G0016541
 protein coding gene Chr1:176382035-176421145 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017179
 protein coding gene Chr1:183837405-183880311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014885
 protein coding gene Chr1:162354686-162395036 (+)
CAST/EiJ MGP_CASTEiJ_G0016121
 protein coding gene Chr1:175741900-175783170 (+)
CBA/J MGP_CBAJ_G0016515
 protein coding gene Chr1:190373516-190420212 (+)
DBA/2J MGP_DBA2J_G0016622
 protein coding gene Chr1:169588719-169628391 (+)
FVB/NJ MGP_FVBNJ_G0016619
 protein coding gene Chr1:167841619-167880828 (+)
LP/J MGP_LPJ_G0016693
 protein coding gene Chr1:179018828-179060297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016646
 protein coding gene Chr1:197639734-197679904 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017215
 protein coding gene Chr1:175672149-175713491 (+)
PWK/PhJ MGP_PWKPhJ_G0015907
 protein coding gene Chr1:168960453-169000362 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015689
 protein coding gene Chr1:174612824-174657626 (+)
WSB/EiJ MGP_WSBEiJ_G0016183
 protein coding gene Chr1:175827537-175867155 (+)



Homology
more
  • Human Ortholog
    COPA, COPI coat complex subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPA, COPI coat complex subunit alpha
  • Synonyms
    AIAISD, AILJK, alpha-COP, HEP-COP
  • Links
    NCBI Gene ID: 1314
    neXtProt AC: NX_P53621
    UniProt: P53621

  • Chr Location
    1q23.2; chr1:160288594-160343566 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Copa mouse models; 1 with human COPA associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    8
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026553 Ensembl Gene Model | MGI Sequence Detail 39802 C57BL/6J ±  kb
    transcript ENSMUST00000027833 Ensembl | MGI Sequence Detail 4351 Not Applicable  
    polypeptide ENSMUSP00000027833 Ensembl | MGI Sequence Detail 1233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 16
      cDNA 21
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138485
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:333810 Elenbaas JS, et al., SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Nat Commun. 2023 Feb 15;14(1):850
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory