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Bub3 Gene Detail
Summary
  • Symbol
    Bub3
  • Name
    BUB3 mitotic checkpoint protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343463
    NCBI Gene: 12237
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:131162081-131173625 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 74.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343463
 protein coding gene Chr7:131161951-131173625 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033108
 protein coding gene Chr7:136199667-136212312 (+)
A/J MGP_AJ_G0033090
 protein coding gene Chr7:132473954-132485468 (+)
AKR/J MGP_AKRJ_G0033022
 protein coding gene Chr7:135985502-135997021 (+)
BALB/cJ MGP_BALBcJ_G0033091
 protein coding gene Chr7:132154690-132166539 (+)
C3H/HeJ MGP_C3HHeJ_G0032805
 protein coding gene Chr7:135833384-135845800 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033602
 protein coding gene Chr7:141404323-141417100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030573
 protein coding gene Chr7:133738033-133749229 (+)
CAST/EiJ MGP_CASTEiJ_G0032135
 protein coding gene Chr7:127689665-127702747 (+)
CBA/J MGP_CBAJ_G0032778
 protein coding gene Chr7:146257945-146269434 (+)
DBA/2J MGP_DBA2J_G0032930
 protein coding gene Chr7:130453759-130465634 (+)
FVB/NJ MGP_FVBNJ_G0032883
 protein coding gene Chr7:130313776-130325309 (+)
LP/J MGP_LPJ_G0033024
 protein coding gene Chr7:137692628-137704926 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032915
 protein coding gene Chr7:147196495-147211242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033622
 protein coding gene Chr7:134978268-134991576 (+)
PWK/PhJ MGP_PWKPhJ_G0031841
 protein coding gene Chr7:123483605-123505418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031687
 protein coding gene Chr7:121761374-121773097 (+)
WSB/EiJ MGP_WSBEiJ_G0032246
 protein coding gene Chr7:135880500-135891943 (+)



Homology
more
  • Human Ortholog
    BUB3, BUB3 mitotic checkpoint protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BUB3, BUB3 mitotic checkpoint protein
  • Synonyms
    BUB3L, hBUB3
  • Links
    NCBI Gene ID: 9184
    neXtProt AC: NX_O43684
    UniProt: O43684

  • Chr Location
    10q26.13; chr10:123154402-123170467 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality by E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    7
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12237 NCBI Gene Model | MGI Sequence Detail 11545 C57BL/6J ±  kb
    transcript NM_009774 RefSeq | MGI Sequence Detail 2096 ZRU/MplStud  
    polypeptide Q9WVA3 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004856 mitotic checkpoint protein BUB3
      (term hierarchy)
    • InterPro Domains
      IPR020472 G-protein beta WD-40 repeat
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9WVA3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2142137, MGI:2142160, MGI:2142214, MGI:2142325, MGI:2146981
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:56369 Martinez-Exposito MJ, et al., Retention of the BUB3 checkpoint protein on lagging chromosomes. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8493-8
    • Latest
      J:340663 Yue W, et al., Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation. FASEB J. 2022 Mar;36(3):e22210
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory