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Map3k5 Gene Detail
Summary
  • Symbol
    Map3k5
  • Name
    mitogen-activated protein kinase kinase kinase 5
  • Synonyms
    7420452D20Rik, ASK, ASK1, Mekk5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346876
    NCBI Gene: 26408
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19810218-20018499 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6029 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346876
 protein coding gene Chr10:19809847-20018499 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017051
 protein coding gene Chr10:17666233-17877852 (+)
A/J MGP_AJ_G0017029
 protein coding gene Chr10:16993973-17193706 (+)
AKR/J MGP_AKRJ_G0016993
 protein coding gene Chr10:17266899-17498789 (+)
BALB/cJ MGP_BALBcJ_G0016987
 protein coding gene Chr10:17050012-17263516 (+)
C3H/HeJ MGP_C3HHeJ_G0016812
 protein coding gene Chr10:17602228-17819462 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017449
 protein coding gene Chr10:18097217-18326352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015154
 protein coding gene Chr10:15996665-16192173 (+)
CAST/EiJ MGP_CASTEiJ_G0016394
 protein coding gene Chr10:17478514-17685396 (+)
CBA/J MGP_CBAJ_G0016784
 protein coding gene Chr10:18918727-19152614 (+)
DBA/2J MGP_DBA2J_G0016892
 protein coding gene Chr10:16872062-17079181 (+)
FVB/NJ MGP_FVBNJ_G0016887
 protein coding gene Chr10:16633484-16834094 (+)
LP/J MGP_LPJ_G0016967
 protein coding gene Chr10:17472800-17677459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016917
 protein coding gene Chr10:19180823-19400956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017487
 protein coding gene Chr10:17275400-17484270 (+)
PWK/PhJ MGP_PWKPhJ_G0016179
 protein coding gene Chr10:16744751-16953744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015962
 protein coding gene Chr10:17431385-17627092 (+)
WSB/EiJ MGP_WSBEiJ_G0016456
 protein coding gene Chr10:17360919-17571129 (+)



Homology
more
  • Human Ortholog
    MAP3K5, mitogen-activated protein kinase kinase kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K5, mitogen-activated protein kinase kinase kinase 5
  • Synonyms
    ASK1, MAPKKK5, MEKK5
  • Links
    NCBI Gene ID: 4217
    neXtProt AC: NX_Q99683
    UniProt: Q99683

  • Chr Location
    6q23.3; chr6:136557046-136793097 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAP3K5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are overtly normal, however apoptosis abnormalities are evident in cultured cells and after induced heart damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1058
  • Tissues
    253
  • cDNA Data
    35
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071369 Ensembl Gene Model | MGI Sequence Detail 208282 C57BL/6J ±  kb
    transcript ENSMUST00000095806 Ensembl | MGI Sequence Detail 5450 Not Applicable  
    polypeptide ENSMUSP00000093485 Ensembl | MGI Sequence Detail 1380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 35
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1101761, MGI:2445207
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 12
      Gene Ontology 17
      Phenotypes 74
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350744 Zhao F, et al., Apoptosis signal-regulating kinase 1 (Ask1) deficiency alleviates MPP(+)-induced impairment of evoked dopamine release in the mouse hippocampus. Front Cell Neurosci. 2024;18:1288991
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory