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Adamts7 Gene Detail
Summary
  • Symbol
    Adamts7
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 7
  • Synonyms
    ADAM-TS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347346
    NCBI Gene: 108153
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:90041420-90082155 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347346
 protein coding gene Chr9:90041420-90090124 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035121
 protein coding gene Chr9:91105445-91155685 (+)
A/J MGP_AJ_G0035102
 protein coding gene Chr9:87953362-87998206 (+)
AKR/J MGP_AKRJ_G0035034
 protein coding gene Chr9:90026403-90071195 (+)
BALB/cJ MGP_BALBcJ_G0035094
 protein coding gene Chr9:87609392-87654943 (+)
C3H/HeJ MGP_C3HHeJ_G0034805
 protein coding gene Chr9:90476896-90523096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035615
 protein coding gene Chr9:93651139-93706081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032518
 protein coding gene Chr9:86126597-86172483 (+)
CAST/EiJ MGP_CASTEiJ_G0034117
 protein coding gene Chr9:90253312-90300782 (+)
CBA/J MGP_CBAJ_G0034773
 protein coding gene Chr9:96901021-96950504 (+)
DBA/2J MGP_DBA2J_G0034935
 protein coding gene Chr9:87501300-87546231 (+)
FVB/NJ MGP_FVBNJ_G0034881
 protein coding gene Chr9:86527726-86572665 (+)
LP/J MGP_LPJ_G0035014
 protein coding gene Chr9:91342840-91392115 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034922
 protein coding gene Chr9:98512548-98558312 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035635
 protein coding gene Chr9:90253037-90298826 (+)
PWK/PhJ MGP_PWKPhJ_G0033824
 protein coding gene Chr9:87677305-87723053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033658
 protein coding gene Chr9:90322027-90366626 (+)
WSB/EiJ MGP_WSBEiJ_G0034237
 protein coding gene Chr9:90139503-90185596 (+)



Homology
more
  • Human Ortholog
    ADAMTS7, ADAM metallopeptidase with thrombospondin type 1 motif 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS7, ADAM metallopeptidase with thrombospondin type 1 motif 7
  • Synonyms
    ADAM-TS 7, ADAM-TS7, ADAMTS-7
  • Links
    NCBI Gene ID: 11173
    neXtProt AC: NX_Q9UKP4
    UniProt: Q9UKP4

  • Chr Location
    15q25.1; chr15:78759206-78811464 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased lung function parameters, reduced endothelial cell migration and proliferation, increased re-endothelialization and ameliorated neointima formation after carotid artery injury, and increased oval cell activation and biliary fibrosis after liver injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    13
  • cDNA Data
    39
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108153 NCBI Gene Model | MGI Sequence Detail 40736 C57BL/6J ±  kb
    transcript NM_001326351 RefSeq | MGI Sequence Detail 5496 Not Specified  
    polypeptide Q68SA9 UniProt | EBI | MGI Sequence Detail 1657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 39
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
    • Latest
      J:330623 Jaiswal AK, et al., ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses. Lung. 2022 Jun;200(3):305-313
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory